EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.24.62 | more |
peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding |
Bos taurus |
? |
- |
? |
3.4.24.62 | peptide I + H2O |
- |
Bos taurus |
? |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin + H2O |
involved in post-translational processing |
Homo sapiens |
? |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin + H2O |
primary cleavage at the Arg12-Ala13 bond |
Homo sapiens |
? |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin + H2O |
primary cleavage at the Arg12-Ala13 bond |
Bos taurus |
? |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin(1-20) + H2O |
obtained by hemisynthesis |
Bos taurus |
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) |
i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) |
? |
3.4.24.62 | Pro-oxytocin/neurophysin(1-20) + H2O |
synthetic eicosapeptide reproducing the entire sequence of amino-terminal domain of bovine proOc/Np precursor |
Bos taurus |
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin(1-20) + H2O |
strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 |
Bos taurus |
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) |
- |
? |
3.4.24.62 | Pro-oxytocin/neurophysin(1-20) + H2O |
strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 |
Homo sapiens |
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) |
i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) |
? |
3.4.24.62 | Pro-oxytocin/neurophysin(1-20) + H2O |
strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 |
Bos taurus |
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) |
i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) |
? |