3.4.24.62 additional information overview Bos taurus ? - ? 89 3.4.24.62 additional information No substrates are Nle11 or Nle12 Bos taurus ? - ? 89 3.4.24.62 additional information relationship between structure and enzyme action Bos taurus ? - ? 89 3.4.24.62 additional information No substrates are Ala9, Val7 Bos taurus ? - ? 89 3.4.24.62 additional information No substrates are D-Lys11 Bos taurus ? - ? 89 3.4.24.62 additional information specificity depends on the organization of a beta-turn-alpha-helix of nine or more residues containing the basic amino acid doublet near the centre Bos taurus ? - ? 89 3.4.24.62 additional information No substrates are oxytocin/neurophysin Bos taurus ? - ? 89 3.4.24.62 additional information structural requirements of the substrate peptides (pro-OT/Np-model) Bos taurus ? - ? 89 3.4.24.62 additional information No substrates are pro-oxytocin/neurophysin peptides (i.e. pro-OT/Np(1-20)) with D-Arg12 Bos taurus ? - ? 89 3.4.24.62 additional information peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding Homo sapiens ? - ? 89 3.4.24.62 additional information peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding Bos taurus ? - ? 89 3.4.24.62 peptide I + H2O - Bos taurus ? - ? 453299 3.4.24.62 Pro-oxytocin/neurophysin + H2O involved in post-translational processing Homo sapiens ? - ? 369556 3.4.24.62 Pro-oxytocin/neurophysin + H2O primary cleavage at the Arg12-Ala13 bond Homo sapiens ? - ? 369556 3.4.24.62 Pro-oxytocin/neurophysin + H2O primary cleavage at the Arg12-Ala13 bond Bos taurus ? - ? 369556 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O obtained by hemisynthesis Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O synthetic eicosapeptide reproducing the entire sequence of amino-terminal domain of bovine proOc/Np precursor Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) - ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) - ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 Homo sapiens Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13 Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O i.e. model substrate peptide I Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) - ? 17245 3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O i.e. model substrate peptide I Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20) i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III) ? 17245 3.4.24.62 [Ala10]-Pro-oxytocin/neurophysin(1-20) + H2O - Bos taurus ? - ? 17247 3.4.24.62 [Ala10]-Pro-oxytocin/neurophysin(1-20) + H2O i.e. peptide XI, hydrolysis at the same rate as pro-oxytocin/neurophysin(1-20) Bos taurus ? - ? 17247 3.4.24.62 [Arg11,Lys12]-Pro-oxytocin/neurophysin(1-20) + H2O i.e. peptide VI, hydrolysis at the same rate as pro-oxytocin/neurophysin(1-20) Bos taurus ? - ? 17246