EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.39 | Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu + H2O |
- |
Plasmodium falciparum |
Lys-Pro-Phe-Glu-Phe + Phe(NO2)-Arg-Leu |
- |
? |
| 3.4.23.39 | Lys-Pro-Ser-Glu-Phe-Phe(NO2)-Arg-Leu + H2O |
- |
Plasmodium falciparum |
Lys-Pro-Ser-Glu-Phe + Phe(NO2)-Arg-Leu |
- |
? |
| 3.4.23.39 | Lys-Ser-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O |
- |
Plasmodium falciparum |
Lys-Ser-Ile-Glu-Phe + Phe(NO2)-Arg-Leu |
- |
? |
| 3.4.23.39 | more |
the enzyme has a preference for a small hydrophobic residue in the P3 position of the substrate. The S2 and S3 subsites of plasmepsin II are hydrophobic in nature and on this basis the hemoglobin-related substrate, with Arg and Thr in the P3 and P2 positions respectively may not represent the optimal substrate |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.39 | more |
multiple explicit-water molecular dynamics simulations of plasmepsin II, uncomplexed and with a hydroxypropylamine peptidomimetic inhibitor, indicate that protonation of Asp214 favours a stable active site structure |
Plasmodium sp. |
? |
- |
? |
| 3.4.23.39 | Myoglobin + H2O |
horse myoglobin is used |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.39 | p47phox-PX + H2O |
PX domain of p47phox, a cytosolic factor of the neutrophil NADPH oxydase is digested |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.39 | plasmepsin 2 + H2O |
PSM2 auto-cleavage after F112 is complete after 20 min in 10 mM citrate pH 4.5 |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.39 | protein 4.1 + H2O |
- |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.39 | spectrin + H2O |
- |
Plasmodium falciparum |
? |
- |
? |
