EC Number   |
General Information |
Reference |
|---|
   7.3.2.6 | metabolism |
Campylobacter jejuni possesses a specific, ultra high affinity tungstate transporter that supplies tungsten for incorporation into formate dehydrogenase, in additon to a molybdate/tungstate transporter ModA, EC 3.6.3.29, and also two MoeA paralogues which may explain the formation of both molybdopterin and tungstopterin in this bacterium |
713053 |
| 7.3.2.6 | metabolism |
ModE-like protein regulates both transporters, repressing mod, EC 3.6.3.29, in the presence of both molybdenum and tungsten and tup only in the presence of tungsten. Like other ModE proteins, the Campylobacter jejuni ModE binds DNA through a helix-turn-helix DNA binding domain, but unlike other members of the ModE family it does not have a metal binding domain |
713054 |
| 7.3.2.6 | metabolism |
specific high-affinity ATP-binding cassette (ABC) transporting systems uptake molybdenum and tungsten in the form of soluble oxyanions, molybdate and tungstate. Among them are the bacterial TupABC transporting system, which is highly specific for tungstate and does not transport other anions, and the ModABC system, which can transport both molybdate and tungstate, regulation of the ModABC transport system. TunR proteins participate in protection of the cells from the inhibition by these oxyanions |
-, 734088 |
| 7.3.2.6 | metabolism |
tupABC gene encoded enzymes participate in the biosynthesis of the pterin cofactor that is present in molybdenum- and tungsten-containing enzymes except nitrogenase |
-, 712348 |
| 7.3.2.6 | more |
cj1540 (tupA) mutant shows a low cellular tungsten content, and a decrase in formate dehydrogenase activity by about 50% in the tupA strain. Supplementation of the growth medium with tungstate significantly increases formate dehydrogenase activity in the wild-type, while inhibiting known molybdoenzymes |
713053 |
| 7.3.2.6 | more |
three-dimensional structure modeling |
735177 |
| 7.3.2.6 | physiological function |
afModBCA is a high-affinity transport system for molybdate and tungstate anions |
735177 |
| 7.3.2.6 | physiological function |
Campylobacter jejuni possesses a specific, ultra high affinity tungstate transporter that supplies tungsten for incorporation into formate dehydrogenase, in additon to a molybdate/tungstate transporter ModA, EC 3.6.3.29 |
713053 |
| 7.3.2.6 | physiological function |
regulator family, tungstate-responsive regulator (TunR) controls the homeostasis of tungstate and molybdate in sulfate-reducing delta-proteobacteria, activation of modA and modBC genes by TunR in Desulfovibrio vulgaris in vivo by a ModE-like regulatory mechanism |
-, 734088 |
| 7.3.2.6 | physiological function |
the enzyme provides tungsten for incorporation into the format dehydrogenase, formate dehydrogenase is active in the presence of either tungsten or molybdenum |
713054 |
