EC Number   |
General Information |
Reference |
|---|
   3.4.24.80 | evolution |
membrane-type matrix metalloproteinase 1 (MT1-MMP, also MMP14) is a type I membrane protein belonging to the MT-MMP family |
753906 |
| 3.4.24.80 | malfunction |
a single mutation in the putative membrane interaction region of MT1-MMP (Ser466Pro) results in lower enzyme activation by bicelles |
755435 |
| 3.4.24.80 | malfunction |
Cartoon mice harbor the single point mutation S466P in the MT1-MMP hemopexin domain, a 200-amino acid segment. The S466P substitution generates a misfolded, temperature-sensitive mutant that is abnormally retained in the endoplasmic reticulum (ER). The MT1-MMPS466P mutation replicates the phenotypic status of Mt1-mmp-null animals as well as the functional characteristics of MT1-MMP-/- cells. The wild-type hemopexin domain does not play a required role in regulating MT1-MMP trafficking, as a hemopexin domain-deletion mutant is successfully mobilized to the cell surface and displays nearly normal collagenolytic activity. Cartoon mice exhibit a pattern of stunted growth, kyphosis, and rounded skulls, Cartoon mouse phenotype, detailed overview. Cartoon mouse fibroblasts are devoid of pericellular collagenolytic activity |
754175 |
| 3.4.24.80 | malfunction |
deletion of the MT1-MMP cytoplasmic tail enhances cell surface activity, with both kcat and KM values affected, while deletion of the hemopexin-like domain negatively impacts KM and increases kcat |
753242 |
| 3.4.24.80 | malfunction |
functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome (WS) phenotype. The WS phenotype includes craniofacial malformations, kyphosis, short-stature, and reduced bone density owing to defective collagen remodeling |
753773 |
| 3.4.24.80 | malfunction |
increased levels of soluble MT1-1/MMP-14 in the serum of breast cancer patients may have implications in the pathogenesis of the disease |
708543 |
| 3.4.24.80 | malfunction |
loss of MMP14 activity increases steady-state vascular leakage, MMP14 activity impacts vascular leakage, mechanism, overview |
708307 |
| 3.4.24.80 | malfunction |
membrane-type 1 matrix metalloproteinase knockdown in DU-145 cells decreases activity of reactive oxygen species 8-hydroxydeoxyguanosine |
720437 |
| 3.4.24.80 | malfunction |
membranous ossifying Weberian vertebral bodies in mmp14a/b KO fish are irregularly shaped, with clusters of multinucleated cells in their dorsal aspect. Mutant mmp14a/b KO fish have abnormal endochondral and membranous ossification, but collagen deposition is unaffected by mmp14a/b KO |
753773 |
| 3.4.24.80 | malfunction |
MMP14 mediates tumor cell surface MHC class I chain-related molecule A shedding, suppression of MMP14 expression blocks MICA shedding, while overexpression of MMP14 enhances it. The regulation is independent of the activity of a disintegrin and metalloproteinases, overview |
709366 |
