Protein Variants | Comment | Organism |
---|---|---|
additional information | suppression of MMP14 expression in human MCF-7 breast cells blocks MHC class I chain-related molecule A, MICA, shedding, while overexpression of MMP14 enhances it, overview | Homo sapiens |
additional information | suppression of MMP14 expression in mouse MyC-CaP prostate cancer cells blocks MHC class I chain-related molecule A, MICA, shedding, while overexpression of MMP14 enhances it, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
pervanadate | a tyrosine phosphatase inhibitor, regulates the activity of MT-MMPs, and accelerates MMP14-mediated shedding of several membrane-anchored proteins | Mus musculus | |
pervanadate | a tyrosine phosphatase inhibitor, regulates the activity of MT-MMPs, and accelerates MMP14-mediated shedding of several membrane-anchored proteins | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
M12 prostate cancer cell | prostate tumor cell line | Homo sapiens | - |
MCF-7 cell | breast tumor cell line | Homo sapiens | - |
Myc-CaP cell | prostate tumor cell line | Mus musculus | - |
PC-3 cell | prostate tumor cell line | Homo sapiens | - |
TRAMP-C2 cell | prostate tumor cell line | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
membrane type matrix metalloproteinase | - |
Mus musculus |
membrane type matrix metalloproteinase | - |
Homo sapiens |
MMP14 | - |
Mus musculus |
MMP14 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | MMP14 mediates tumor cell surface MHC class I chain-related molecule A shedding, suppression of MMP14 expression blocks MICA shedding, while overexpression of MMP14 enhances it. The regulation is independent of the activity of a disintegrin and metalloproteinases, overview | Mus musculus |
malfunction | MMP14 mediates tumor cell surface MHC class I chain-related molecule A shedding, suppression of MMP14 expression blocks MICA shedding, while overexpression of MMP14 enhances it. The regulation is independent of the activity of a disintegrin and metalloproteinases, overview | Homo sapiens |