EC Number |
General Information |
Reference |
---|
3.4.24.79 | malfunction |
down-regulation of enzyme expression and secretion decreases tumor growth after implanted in vivo |
735072 |
3.4.24.79 | malfunction |
enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome |
735323 |
3.4.24.79 | physiological function |
pregnancy-associated plasma protein-A (PAPP-A) acts to enhance tumor growth in vivo. Overexpression of PAPP-A favored development of mature tumor vasculature. PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells |
719372 |
3.4.24.79 | physiological function |
pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor-I bioavailability through cleavage of inhibitory insulin-like growth factor binding protein. Expression of human PAPP-A localized to arterial smooth muscle accelerates lesion progression in a mouse model of atherosclerosis |
718547 |
3.4.24.79 | physiological function |
protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth and progression in vivo |
735072 |
3.4.24.79 | physiological function |
the enzyme can act as an autocrine/paracrine regulator of insulin-like growth factor action |
735323 |
3.4.24.79 | physiological function |
the enzyme induces tissue factor expression in epithelial cells through the activation of Akt/nuclear factor-kappaB axis |
754523 |