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Literature summary for 3.4.24.79 extracted from

  • Conover, C.A.; Mason, M.A.; Bale, L.K.; Harrington, S.C.; Nyegaard, M.; Oxvig, C.; Overgaard, M.T.
    Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development (2010), Am. J. Physiol. Heart Circ. Physiol., 299, H284-H291.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in mouse arterial smooth muscle cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inhibitory insulin-like growth factor binding protein-4 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13219
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inhibitory insulin-like growth factor binding protein-4 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IGFBP-4 protease
-
Homo sapiens
PAPP-A
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Homo sapiens
pregnancy-associated plasma protein-A
-
Homo sapiens

General Information

General Information Comment Organism
physiological function pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor-I bioavailability through cleavage of inhibitory insulin-like growth factor binding protein. Expression of human PAPP-A localized to arterial smooth muscle accelerates lesion progression in a mouse model of atherosclerosis Homo sapiens