Cloned (Comment) | Organism |
---|---|
expressed in mouse arterial smooth muscle cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inhibitory insulin-like growth factor binding protein-4 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13219 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inhibitory insulin-like growth factor binding protein-4 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IGFBP-4 protease | - |
Homo sapiens |
PAPP-A | - |
Homo sapiens |
pregnancy-associated plasma protein-A | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor-I bioavailability through cleavage of inhibitory insulin-like growth factor binding protein. Expression of human PAPP-A localized to arterial smooth muscle accelerates lesion progression in a mouse model of atherosclerosis | Homo sapiens |