EC Number   |
General Information |
Reference |
|---|
   3.4.22.B19 | evolution |
different Yersinia strains exhibit a range of cytotoxic activities on macrophages and this heterogeneity has been linked to allelic variation of genes encoding YopJ/YopP proteins, overview |
-, 732694 |
| 3.4.22.B19 | metabolism |
mechanism of enzme YopJKIM-induced cell death, caspase-1 activation, and IL-1beta secretion in primary murine macrophages, overview. Caspase-3/7 activity is low and the caspase-3 substrate poly (ADP-ribose) polymerase is not cleaved in Yersinia pestis KIM5-infected macrophages. Enzyme YopJKIM-mediated cell death and caspase-1 activation occur independent of mitochondrial-directed apoptosis, Apoptotic signaling through caspase-8 and mitochondria is dispensable for KIM5-induced macrophage death, RIP1 and reactive oxygen species are not required for YopJKIM-induced cell death or IL-beta secretion |
-, 732694 |
| 3.4.22.B19 | physiological function |
deletion of gene YopJ results in significantly increased IL-8 production. Plasmid-encoded effector Yop proteins, particularly YopJ, prevent IL-8 secretion by human polymorphonuclear leukocytes |
754642 |
| 3.4.22.B19 | physiological function |
expression of YopP in Yersinia pestis enhances its cytotoxicity in macrophages and reduces its virulence |
-, 710365 |
| 3.4.22.B19 | physiological function |
the enzyme YopJ is involved in the reduction of maturation markers and immunostimulatory capacity of infected dendritic cells, together with enzymes YopH and mainly YopE, which contributes to the ability of Yersinia pseudotuberculosis to evade adaptive immune responses and subsequently inhibit the host's ability to clear the infection, overview |
731100 |
| 3.4.22.B19 | physiological function |
when expressed in Schizosaccharomyces pombe, YopJ sensitizes cells to osmotic and oxidative stresses through a Hri2-dependent mechanism, however, when co-expressed with Yersinia protein kinase A, YopJ protects cells from Yersinia protein kinase A-mediated toxicity, and this protection is entirely dependent on Hri2. YopJ does not confer protection against the toxic effects of the Yersinia virulence factor YopE |
709046 |
| 3.4.22.B19 | physiological function |
Yersinia outer protein J is a type III secretion system effector of pathogenic Yersinia, i.e. Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis, that is secreted into host cells. YopJ inhibits survival response pathways in macrophages, causing cell death. Allelic variation of enzyme YopJ is responsible for differential cytotoxicity in Yersinia strains. Enzme YopJKIM-induced macrophage death is associated with caspase-1 activation and interleukin-1beta secretion |
-, 732694 |
| 3.4.22.B19 | physiological function |
Yersinia YopJ induces caspase activation in J774A.1 macrophages and human monocyte-derived macrophages. YopJ does not induce pronounced apoptosis in human neutrophils |
710393 |
| 3.4.22.B19 | physiological function |
YopJ deactivates MAPK- and NF-kappaB signaling pathways, and induces apoptosis of immune cells, YopJ inhibits the c-JNK pathway, attenuates the inflammatory responses, and interferes with the cell apoptotic process. When YopJ is replaced with YopP, the YopP-expressing Yersinia pestis strain exhibits high cytotoxic activity against macrophages |
707159 |
| 3.4.22.B19 | physiological function |
YopJ kills macrophages and dendritic cells, reduces their production of tumor necrosis factor alpha and interleukin-12, and promotes systemic colonization in mouse models of intestinal Yersinia infection. YopJ-promoted cytotoxicity and systemic colonization are associated with significant increases in neutrophils in spleens and the proinflammatory cytokines interleukin-18 and gamma interferon in serum samples of mice vaccinated with Yersinia pseudotuberculosis. A proinflammatory, rather than anti-inflammatory, process accompanies YopJ-promoted cytotoxicity leading to increased systemic colonization by Yersinia pseudotuberculosis and potentially enhancing adaptive immunity to a live vaccine |
708720 |
