EC Number |
General Information |
Reference |
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2.4.1.109 | evolution |
PMT family members are conserved throughout the fungal and animal kingdoms. They are further subdivided into the PMT1, PMT2, and PMT4 subfamilies, which include transferases closely related to Saccharomyces cerevisiae Pmt1p, Pmt2p, and Pmt4p, respectively. In fungi, at least one member of each subfamily is present, whereas in animals only PMT2 and PMT4 subfamily members are conserved. In Saccharomyces, Pmt1p, Pmt2p, and Pmt4p account for the major transferase activities although at least six PMTs (Pmt1p-Pmt6p) are present |
736741 |
2.4.1.109 | evolution |
the enzyme is a member of the protein-O-mannosyltransferase (PMT) family. Pichia pastoris has five PMT genes. Based on sequence homology, the PMTs can be grouped into three subfamilies, with both PMT1 and PMT2 subfamilies possessing two members each (PMT1 and PMT5, and PMT2 and PMT6, respectively). The remaining subfamily, PMT4, has only one member, PMT4. PMT1 and PMT2 each play a significant role in O-glycosylation |
-, 737115 |
2.4.1.109 | malfunction |
AnpmtA + AnpmtB double disruptant is viable but slow growing with morphological characteristics cumulative of single disruptants |
708355 |
2.4.1.109 | malfunction |
AnpmtA + AnpmtB double disruptant is viable but slow growing with morphological characteristics cumulative of single disruptants, hyperglycosylation of specific target proteins |
708355 |
2.4.1.109 | malfunction |
AnpmtB disruptant shows wild-type colony formation at 30°C, slightly repressed growth at 42°C, conidiation reduced to about 50%, hyperbranching of hyphae (defect in polarity maintenance) |
708355 |
2.4.1.109 | malfunction |
defects in O-mannosylation are associated with muscular dystrophies (dystroglycanopathies) |
708616 |
2.4.1.109 | malfunction |
dystroglycanopathies (muscular dystrophy due to abnormal glycosylation of alpha-dystroglycan) such as the severe Walker-Warburg syndrome (brain and eye abnormalities, mild limb girdle muscular dystrophy) |
710090 |
2.4.1.109 | malfunction |
loss of the O-mannosyltransferase is associated with a reduced formation frequency of the invasive structure, the appressorium, combined with a loss in the ability to penetrate the plant cuticle |
710329 |
2.4.1.109 | malfunction |
mutation in either one of the complex forming enzymes can lead to Walker-Warburg syndrome, a congenital muscular dystrophy with abnormal neuronal migration |
708957 |
2.4.1.109 | malfunction |
PMT2 knockout, and to a lesser extent a PMT1 knockout, in addition to a reduction in O-glycan site occupancy also leads to shortened O-glycan chain lengths |
-, 737115 |