EC Number   |
General Information |
Reference |
|---|
   2.3.1.199 | malfunction |
complete loss of isoform KCS20 and KCS2 genes decreases the total wax content in stems and leaves by 20% and 15%, respectively. Kcs20 kcs2/daisy-1 double mutants exhibit significant reduction of C22 and C24 very-long-chain fatty acid derivatives but accumulation of C20 very-long-chain fatty acid derivatives in aliphatic suberin |
720703 |
| 2.3.1.199 | malfunction |
complete loss of KCS1 expression results in decreases of up to 80% in the levels of C26 to C30 wax alcohols and aldehydes, while smaller effects are observed on the major wax components, i.e. the C29 alkanes and C29 ketones on leaves, stems and siliques. The loss of KCS1 expression does not result in complete loss of any individual wax component or significantly decrease the total wax load |
720698 |
| 2.3.1.199 | malfunction |
enzyme mutations reduce the amount of wax, but not the total load of cutin in leaf blades, and result in an increased rate of water loss. Enzyme defects affect cuticle structure, water barrier properties of the cuticle and infection by the powdery mildew fungus |
757985 |
| 2.3.1.199 | malfunction |
FAE1 misexpression plants are similar to the wild type but display an essentially glabrous phenotype, owing to the selective death of trichome cells. Nuclei of arrested trichome cells in FAE1 misexpression plants cell-autonomously accumulate high levels of DNA damage, including double-strand breaks characteristic of lipoapoptosis |
720673 |
| 2.3.1.199 | malfunction |
null mutations in ELO3 result in accumulation of labeled precursors into inositol phosphoceramide, with little labeling in the more complex mannosylated sphingolipids, whereas disruption of ELO2 results in reduced levels of all sphingolipids. Mutations in ELO3 lead to elevated levels of C20 and C22 fatty acids (most abundant species is behenic acid which averages 3.1% of the total fatty acyl mass, a 10fold increase over wild type levels). ELO3 disruption results in an approximate 20% increase in the total levels of very long chain species. Sharply reduced levels of cerotic acid (approximately 20% wild type levels) and hydroxy-cerotic acid (approximately 40% of wild type levels) are found in an elo2 mutant strain |
719791 |
| 2.3.1.199 | malfunction |
suppression of CUT1 in transgenic Arabidopsis plants results in waxless (eceriferum) stems and siliques as well as conditional male sterility. In CUT1-suppressed plants, the C24 chain-length wax components predominate. Both decarbonylation and acyl reduction pathways are down-regulated in cut1-suppressed plants |
720669 |
| 2.3.1.199 | metabolism |
the enzyme is involved in docosahexaenoic acid synthesis pathway in the teleost Solea senegalensis |
744399 |
| 2.3.1.199 | metabolism |
the enzyme is involved in the fatty acid elongation cycle consisting of the reaction steps of condensation, reduction, dehydration, and reduction |
737127 |
| 2.3.1.199 | metabolism |
the enzyme is involved in very-long-chain fatty acid elongation beyond C22. Elongation beyond C24 requires the participation of CER2 |
758040 |
| 2.3.1.199 | physiological function |
3-ketoacyl-CoA reductase, KAR, regulates enzyme ELOVL6 via two modes: in the first mode, KAR may induce conformational changes in ELOVL6 to become a structure that can undergo catalysis. In the second mode, conversion of 3-oxoacyl-CoA to 3-hydroxyacyl-CoA by KAR may facilitate release of the product from the presumed ELOVL6-KAR complex |
737127 |
