EC Number   |
General Information |
Reference |
|---|
   2.1.1.183 | malfunction |
a conditional GAL1O::diml strain is constructed to allow the depletion of Dimlp from the cell. During depletion, dimethylation of the pre-rRNA is progressively inhibited and pre-rRNA processing at cleavage sites A1 and A2 is concomitantly lost. In consequence, the mature 18s rRNA and its 20s precursor drastically underaccumulate. This has the effect of preventing the synthesis of nonmethylated rRNA |
703858 |
| 2.1.1.183 | malfunction |
disruption of DIM1 is lethal |
705108 |
| 2.1.1.183 | malfunction |
isolation of mutations that uncouple the enzymatic function of Dim1p in methylation from its involvement in prerRNA processing |
705680 |
| 2.1.1.183 | malfunction |
neither the bacterial nor the archaeal ortholog could complement for the eukaryotic Dim1. This might be related to the secondary, non-methyltransferase function that Dim1 is known to play in eukaryotic ribosomal maturation |
705155 |
| 2.1.1.183 | physiological function |
DIM1 is involved in pre-rRNA processing |
703858 |
