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Literature summary for 2.1.1.183 extracted from

  • Lafontaine, D.; Vandenhaute, J.; Tollervey, D.
    The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast (1995), Genes Dev., 9, 2470-2481.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA Saccharomyces cerevisiae Dim1p is required for pre-ribosomal RNA processing 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae C7GSG6
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA Dim1p is required for pre-ribosomal RNA processing Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
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4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA presence of the 6-dimethyladenine1779/6-dimethyladenine1780 is detected by primer extension Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
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Synonyms

Synonyms Comment Organism
18S rRNA dimethylase Dim1p
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Saccharomyces cerevisiae
Dim1p
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction a conditional GAL1O::diml strain is constructed to allow the depletion of Dimlp from the cell. During depletion, dimethylation of the pre-rRNA is progressively inhibited and pre-rRNA processing at cleavage sites A1 and A2 is concomitantly lost. In consequence, the mature 18s rRNA and its 20s precursor drastically underaccumulate. This has the effect of preventing the synthesis of nonmethylated rRNA Saccharomyces cerevisiae
physiological function DIM1 is involved in pre-rRNA processing Saccharomyces cerevisiae