Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA | Saccharomyces cerevisiae | Dim1p is required for pre-ribosomal RNA processing | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | C7GSG6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA | Dim1p is required for pre-ribosomal RNA processing | Saccharomyces cerevisiae | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA | - |
? | |
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA | presence of the 6-dimethyladenine1779/6-dimethyladenine1780 is detected by primer extension | Saccharomyces cerevisiae | 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
18S rRNA dimethylase Dim1p | - |
Saccharomyces cerevisiae |
Dim1p | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | a conditional GAL1O::diml strain is constructed to allow the depletion of Dimlp from the cell. During depletion, dimethylation of the pre-rRNA is progressively inhibited and pre-rRNA processing at cleavage sites A1 and A2 is concomitantly lost. In consequence, the mature 18s rRNA and its 20s precursor drastically underaccumulate. This has the effect of preventing the synthesis of nonmethylated rRNA | Saccharomyces cerevisiae |
physiological function | DIM1 is involved in pre-rRNA processing | Saccharomyces cerevisiae |