EC Number   |
General Information |
Reference |
|---|
   1.21.99.3 | malfunction |
enzyme-deficient mice of both sexes exhibit decreased adiposity, reduced brown and white adipocyte size, and enhanced fat loss in response to triiodothyronine treatment. They also exhibit increased thyroid hormone action in the hypothalamus, with abnormal expression and triiodothyronine sensitivity of genes integral to the leptin-melanocortin system, including Agrp, Npy, Pomc, and Mc4r. Enzyme-deficient mice also display elevated locomotor activity and increased energy expenditure |
744793 |
| 1.21.99.3 | malfunction |
in Dio3-deficient mice, about 80% of both M opsin+ and S opsin+ cones are lost through neonatal cell death |
715991 |
| 1.21.99.3 | malfunction |
inhibition of deiodinase-3 activity with iopanoic acid alone causes strong inhibition (58%) of blastema formation |
715101 |
| 1.21.99.3 | malfunction |
type 3 deiodinase is the cause of consumptive hypothyroidism, a clinical entity which often requires close cooperation between clinical endocrinologists, pediatricians, and oncologists, pathology, detailed overview |
733907 |
| 1.21.99.3 | metabolism |
physiological role of thyroid hormones in the regulation of insulin secretion, overview. type 3 iodothyronine deiodinase-mediated thyroid hormone inactivation is thought to participate in glucose-stimulated insulin secretion from beta cellsA cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells |
734596 |
| 1.21.99.3 | physiological function |
enzyme-mediated regulation of thyroid hormone action in the central nervous system influences multiple critical determinants of energy balance |
744793 |
| 1.21.99.3 | physiological function |
hepatic type 3 iodothyronine deiodinase in adult vertebrates plays a sentinel role in avoiding an inappropriate overload of exogenous 3,5,3'-triiodo-L-thyronine secondary to feeding in those species that devour the whole prey |
715102 |
| 1.21.99.3 | physiological function |
inactivates thyroid hormone, deiodination |
697638 |
| 1.21.99.3 | physiological function |
inactivation of thyroid hormone |
701299 |
| 1.21.99.3 | physiological function |
mRNA knock-down induces an overall delay in development and a severe delay of the time of hatching. There is a severe disturbance of several aspects of development. Swim bladder development and inflation are aberrant as is the development of liver and intestine. Enzyme knock-down larvae spend significantly less time moving, and both embryos and larvae exhibit perturbed escape responses. Isoform Dio3b mRNA levels in embryos are higher and the effects of Dio3b knock-down on enzymic activity and on the resulting phenotype are more severe than those of Dio2a knock-down |
727368 |
