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Literature summary for 1.21.99.3 extracted from

  • Villalobos, P.; Orozco, A.; Valverde-R, C.
    Molecular cloning and characterization of a type 3 iodothyronine deiodinase in the pine snake Pituophis deppei (2010), Gen. Comp. Endocrinol., 169, 167-173.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Xenopus laevis oocytes Pituophis deppei

Inhibitors

Inhibitors Comment Organism Structure
6-Propyl-2-thiouracil
-
Pituophis deppei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000094
-
3,5,3'-triiodo-L-thyronine recombinant enzyme, at 30°C, at pH 7.0, with 50 mM dithiothreitol Pituophis deppei
0.0000098
-
3,5,3'-triiodo-L-thyronine native enzyme, at 30°C, at pH 7.0, with 50 mM dithiothreitol Pituophis deppei

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Pituophis deppei
-
-

Organism

Organism UniProt Comment Textmining
Pituophis deppei D2J363 pine snake
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Pituophis deppei
-
gut
-
Pituophis deppei
-
heart
-
Pituophis deppei
-
liver
-
Pituophis deppei
-
muscle
-
Pituophis deppei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5,3'-triiodo-L-thyronine + AH2 highest substrate affinity for 3,5,3'-triiodo-L-thyronine Pituophis deppei 3,3'-diiodothyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
type 3 iodothyronine deiodinase
-
Pituophis deppei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Pituophis deppei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Pituophis deppei

Cofactor

Cofactor Comment Organism Structure
dithiothreitol the enzyme requires a high concentration of cofactor (40 mM dithiothreitol) Pituophis deppei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.8
-
6-Propyl-2-thiouracil at 30°C, at pH 7.0, with 50 mM dithiothreitol Pituophis deppei

General Information

General Information Comment Organism
physiological function hepatic type 3 iodothyronine deiodinase in adult vertebrates plays a sentinel role in avoiding an inappropriate overload of exogenous 3,5,3'-triiodo-L-thyronine secondary to feeding in those species that devour the whole prey Pituophis deppei