Cloned (Comment) | Organism |
---|---|
expressed in Xenopus laevis oocytes | Pituophis deppei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Propyl-2-thiouracil | - |
Pituophis deppei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000094 | - |
3,5,3'-triiodo-L-thyronine | recombinant enzyme, at 30°C, at pH 7.0, with 50 mM dithiothreitol | Pituophis deppei | |
0.0000098 | - |
3,5,3'-triiodo-L-thyronine | native enzyme, at 30°C, at pH 7.0, with 50 mM dithiothreitol | Pituophis deppei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Pituophis deppei | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pituophis deppei | D2J363 | pine snake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Pituophis deppei | - |
gut | - |
Pituophis deppei | - |
heart | - |
Pituophis deppei | - |
liver | - |
Pituophis deppei | - |
muscle | - |
Pituophis deppei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,5,3'-triiodo-L-thyronine + AH2 | highest substrate affinity for 3,5,3'-triiodo-L-thyronine | Pituophis deppei | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 3 iodothyronine deiodinase | - |
Pituophis deppei |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Pituophis deppei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Pituophis deppei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | the enzyme requires a high concentration of cofactor (40 mM dithiothreitol) | Pituophis deppei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
4.8 | - |
6-Propyl-2-thiouracil | at 30°C, at pH 7.0, with 50 mM dithiothreitol | Pituophis deppei |
General Information | Comment | Organism |
---|---|---|
physiological function | hepatic type 3 iodothyronine deiodinase in adult vertebrates plays a sentinel role in avoiding an inappropriate overload of exogenous 3,5,3'-triiodo-L-thyronine secondary to feeding in those species that devour the whole prey | Pituophis deppei |