EC Number   |
General Information |
Reference |
|---|
    1.14.99.1 | more |
aqueous extracts of Chromoleana odorata, commonly used in traditional medicine as antiinflammatory drug against pains or as cataplasm to stop hemorrhage in Ivory Coast, the essential oil extracted from the fresh leaves activates the cyclooxygenase activity of the PGHS, overview |
713706 |
| 1.14.99.1 | malfunction |
cervical distensibility is decreased in enzyme knockout mice on the day of expected delivery. Delayed parturition in enzyme knockout mice is the result of impaired luteolysis and cervical dilation |
744794 |
| 1.14.99.1 | more |
neurotoxicity of the amphetamine analogues methamphetamine and 3,4-methylenedioxyamphetamine, the active metabolite of ecstasy, may involve their prostaglandin H synthase-dependent bioactivation to free radical intermediates that generate reactive oxygen species and oxidatively damage cellular macromolecules. The activation effect is blocked by irreversible enzyme inhibitor acetylsalicylic acid, overview |
716959 |
| 1.14.99.1 | physiological function |
periovulatory expression of the Ptgs2 gene is essential for ovulation |
697636 |
| 1.14.99.1 | physiological function |
PGHS is involved in inflammation processes |
713706 |
| 1.14.99.1 | malfunction |
PGHS-1 inhibition in activated human plateletts significantly decreases PGHS-1-dependent thromboxane B2 formation in parallel with a decrease in platelet aggregation |
727873 |
| 1.14.99.1 | physiological function |
PGHS-2 also shows cyclooxygenase activity, which is implicated in colorectal cancer |
716434 |
| 1.14.99.1 | more |
PHS is involved in the mechanism of thalidomide to cause increased embryonic DNA oxidation measured as 8-oxoguanine leading to embryopathies, phenotype, overview. A prostaglandin H synthase-dependent, reactive oxygen species-mediated mechanism. Thalidomide teratogenicity was blocked by maternal pretreatment with acetylsalicylic acid, an irreversible inhibitor of prostaglandin H synthase |
714943 |
| 1.14.99.1 | physiological function |
PHS isozyme-dependent oxidative damage to proteins and DNA, and cytotoxicity, overview. hPHS-1- and hPHS-2-expressing cells incubated with dopamine, L-dihydroxyphenylalanine, dihydroxyphenylacetic acid, or homovanillic acid exhibit increased cytotoxicity compared to untransfected cells, and cytotoxicity is increased further by exogenous arachidonic acid, which increases hPHS activity. Isozyme-specific, PHS-dependent oxidative damage and cytotoxicity caused by neurotransmitters, their precursors, and their metabolites may contribute to neurodegeneration associated with aging |
715090 |
| 1.14.99.1 | metabolism |
prostaglandin H synthase-1 catalyzes the first two steps in prostaglandin synthesis |
728736 |
