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EC Number Expression Commentary Reference
Show all pathways known for 1.3.99.4Display the word mapDisplay the reaction diagram Show all sequences 1.3.99.4more construction of a mutant Mtb H37Rv strain containing an inactivated kstD gene, DELTAkstD, which encodes 3-ketosteroid 1(2)-dehydrogenase by homologous recombination-based gene-replacement technique. Replication of mutant Mycobacterium tuberculosis is attenuated in resting human macrophages compared to the wild-type or complemented strains. The mutant is unable to inhibit the NO and reactive oxygen species production induced through Toll-like receptor 2 signaling in infected resting macrophages. But mutant and wild-type Mycobacterium tuberculosis behave similarly in macrophages activated with IFN-gamma before and during infection. The mutant is unable to use cholesterol as a source of carbon and energy and has a limited ability to multiply -, 724670
Show all pathways known for 1.3.99.4Display the word mapDisplay the reaction diagram Show all sequences 1.3.99.4up the enzyme is induced during the bacterial growth on 17alpha-methyl-testosterone -, 763042
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