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Information on EC 1.3.99.4 - 3-oxosteroid 1-dehydrogenase
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1.3.99.4 3-oxosteroid 1-dehydrogenaseSpecify your search results
Word Map
- 1.3.99.4
- rhodococcus
- 3-ketosteroids
- mycobacterium
- cholesterol
- 4-androstene-3,17-dione
- erythropolis
- synthesis
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arthrobacter
- simplex
- isoenzymes
- testosteroni
- rhodochrous
- androst-4-ene-3,17-dione
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bioconversion
- hydrocortisone
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dehydrogenation
- phytosterols
- ruber
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steroid-transforming
- globiformis
- 1,4-androstadiene-3,17-dione
- neoaurum
- molecular biology
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
kstd2, kstd3, kstd1, ksdd3, ksdd1, steroid-1-dehydrogenase, delta1-dehydrogenase, ksdd2, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-delta1-dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-ene-dehydrogenase
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3-keto-5alpha-steroid DELTA(1)-dehydrogenase
3-ketosteroid 1(2)-dehydrogenase
3-ketosteroid delta1-dehydrogenase
3-ketosteroid-1-en-dehydrogenase
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3-ketosteroid-D1-dehydrogenase
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3-ketosteroid-DELTA1-dehydrogenase
3-ketosteroid-DELTA1-dehydrogenases
3-oxosteroid D1-dehydrogenase
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3-oxosteroid Delta1-dehydrogenase
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3-oxosteroid:(2,6-dichlorphenolindophenol) DELTA1-oxidoreductase
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3-oxosteroid:(2,6-dichlorphenolindophenol)D1-oxidoreductase
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4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase
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4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase
4-ene-3-oxosteroid:(acceptor)l-ene-oxidoreductase
D1-dehydrogenase
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D1-steroid reductase
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dehydrogenase, 3-oxo steroid Delta 1-
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Delta1-dehydrogenase
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DELTA1-KstD
DELTA1-KSTD1
DELTA1-steroid reductase
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ketosteroid DELTA1-dehydrogenase
KsdD
KsdD1
KsdD2
KsdD3
KsdD5
KsdDM
KstD
KSTD1
KSTD2
KSTD3
KSTD3 orthologue
KstDF
MnKstD1
MnKstD2
MsKstD1
MsKstD2
MsKstD3
MsKstD4
ReKstD1
Rv3537
steroid-1-dehydrogenase
3-keto-5alpha-steroid DELTA(1)-dehydrogenase
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3-ketosteroid-DELTA1-dehydrogenase
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4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase
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4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a 3-oxosteroid + acceptor = a 3-oxo-DELTA1-steroid + reduced acceptor
stereochemistry: trans-diaxial
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a 3-oxosteroid + acceptor = a 3-oxo-DELTA1-steroid + reduced acceptor
ping-pong bi bi mechanism
a 3-oxosteroid + acceptor = a 3-oxo-DELTA1-steroid + reduced acceptor
sequential linear mechanism
a 3-oxosteroid + acceptor = a 3-oxo-DELTA1-steroid + reduced acceptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
3-oxosteroid:acceptor DELTA1-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9029-04-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5alpha,17beta)-17-hydroxyandrostan-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
11-deoxy-17alpha-hydroxycorticosterone + acceptor
17,21-dihydroxypregna-1,4-diene-3,20-dione + reduced acceptor
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4-pregnene-17alpha,21-diol-3,20-dione
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?
11-deoxycorticosterone + acceptor
21-hydroxypregna-1,4-diene-3,20-dione + reduced acceptor
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?
11alpha-hydroxy-testosterone + acceptor
11alpha,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
-
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?
11alpha-hydroxyprogesterone + acceptor
11alpha-hydroxy-1,4-pregnene-3,20-dione + reduced acceptor
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4-pregnene-11alpha-ol-3,20-dione
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?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + 2,6-dichlorphenolindophenol
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced 2,6-dichlorphenolindophenol
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + phenazine methosulfate
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced phenazine methosulfate
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione acetate + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione acetate + reduced acceptor
11beta-cortisol + 2,6-dichlorophenol-indophenol
(11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
11beta-hydroxy-4-androstene-3,17-dione + acceptor
11beta-hydroxy-1,4-androstene-3,17-dione + reduced acceptor
11beta-hydroxytestosterone + acceptor
11beta,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
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4-androstene-11beta,17beta-diol-3-one
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?
16,17alpha-epoxyprogesterone + acceptor
? + reduced acceptor
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?
17-methyl-testosterone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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?
17alpha,21-dihydroxyprogesterone 21-acetate + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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Reichstein substance S 21-acetate (RSA), best substrate
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?
17alpha,21-dihydroxyprogesterone 21-acetate + acceptor
? + reduced acceptor
RSA
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?
17alpha-hydroxy-progesterone + acceptor
1,4-pregnene-17alpha-ol-3,20-dione + reduced acceptor
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4-pregnene-17alpha-ol-3,20-dione
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?
17alpha-hydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha-ol-3,20-dione + reduced acceptor
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?
17alpha-hydroxyprogesterone + 2,6-dichlorophenol-indophenol
17alpha-hydroxy-pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
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?
17alpha-hydroxyprogesterone + acceptor
17alpha-hydroxy-pregna-1,4-diene-3,20-dione + reduced acceptor
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?
17alpha-methyltestosterone + acceptor
17alpha-methylandrost-1,4-diene-3-one + reduced acceptor
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?
19-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
19-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
19-nor-4-androstene-3,17-dione + acceptor
19-nor-1,4-androstene-3,17-dione + reduced acceptor
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4-estren-3,17-dione
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?
19-nortestosterone + acceptor
17beta-hydroxy-1,4-estrene-3-one + reduced acceptor
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4-estren-17beta-ol-3-one
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?
22-hydroxy-23, 24-bisnorchola-4-en-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
25-hydroxycholest-4-en-3-one + acceptor
? + reduced acceptor
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?
3-oxo-5beta-cholan-24-oic acid + acceptor
? + reduced acceptor
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?
3-oxosteroid + acceptor
3-oxo-DELTA1-steroid + reduced acceptor
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key catalyst in microbial steroid metabolism
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?
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
4-androstene-3,11,17-trione + acceptor
1,4-androstene-3,11,17-trione + reduced acceptor
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?
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstadiene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
4-androstene-3,17-dione + phenazine methosulfate
1,4-androstadiene-3,17-dione + reduced phenazine methosulfate
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r
4-androstene-3,17-dione + phenazine methosulfate
1,4-androstene-3,17-dione + reduced phenazine methosulfate
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?
4-cholesten-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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?
4-cholesten-3-one + acceptor
? + reduced acceptor
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?
4-pregnen-3-one-20beta-carboxylic acid + 2,6-dichlorophenol-indophenol
pregna-1,4-dien-3-one-20beta-carboxylic acid + reduced 2,6-dichlorophenol-indophenol
5alpha-androst-1-en-3-one + acceptor
5alpha-androstan-3-one + reduced acceptor
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?
5alpha-androstan-3-one-17beta-ol + 2,6-dichlorophenol-indophenol
(5alpha,17beta)-17-hydroxyandrost-1-en-3-one + reduced 2,6-dichlorophenol-indophenol
5alpha-androstane-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
5alpha-androst-1-ene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
5alpha-androstane-3,17-dione + 2,6-dichlorophenol-indophenol
5beta-androst-1-en-3,17-dione + reduced 2,6-dichlorophenol-indophenol
5alpha-pregnane-3,20-dione + 2,6-dichlorophenol-indophenol
5alpha-pregn-1-en-3,20-dione + reduced 2,6-dichlorophenol-indophenol
5beta-androstan-3,17-dione + acceptor
5beta-androst-1-en-3,17-dione + reduced acceptor
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?
6-dehydrotestosterone acetate + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
9,22-dihydroxy-23,24-bisnorchol-4-ene-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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?
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced 2,6-dichlorophenol-indophenol
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxyandrost-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
9alpha-hydroxy-4-androstene-3,17-dione + acceptor
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced acceptor
9alpha-hydroxy-4-androstene-3,17-dione + acceptor
? + reduced acceptor
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?
9alpha-hydroxy-4-androstene-3,17-dione + FAD
9alpha-hydroxy-1,4-androstadiene-3,17-dione + FADH2
androsta-4,9(11)-diene-3,17-dione + acceptor
? + reduced acceptor
NSC 44826
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?
androsterone + acceptor
3-alpha-hydroxy-1-androstene-17-one + reduced acceptor
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4-androstene-3,11,17-trione
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?
canrenone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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best substrate
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?
corticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
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?
corticosterone + acceptor
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced acceptor
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4-pregnene-11beta,21-diol-3,20-dione
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?
cortisol + acceptor
prednisolone + reduced acceptor
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optimal concentration is 0.1 mg/ml, increase of concentration to 1 mg/ml reduces prednisolone yield
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?
cortisone acetate + 2,6-dichlorophenol-indophenol
prednisolone acetate + reduced 2,6-dichlorophenol-indophenol
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?
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnadiene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
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?
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
deoxycorticosterone + acceptor
1,4-pregnene-21-ol-3,20-dione + reduced acceptor
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4-pregnene-21-ol-3,20-dione
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?
hydrocorticosterone + acceptor
1,4-pregnene-11beta,17alpha,21-triol-3,20-dione + reduced acceptor
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4-pregnene-11beta,17alpha,21triol-3,20-dione
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?
hydrocortisone 21-hemisuccinate + acceptor
? + reduced acceptor
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?
pregna-4,9(11),16-triene-3,20-dione + acceptor
? + reduced acceptor
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?
progesterone + 2,6-dichlorophenol-indophenol
pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
testololactone + acceptor
D-homo-17alpha-oxoandrosta-1,4-diene-3,17-one + reduced acceptor
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D-homo-17a-oxoandrost-4-ene-3,17-dione
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?
testosterone + 2,6-dichlorophenol-indophenol
17beta-hydroxyandrost-1,4-diene-3-one + reduced 2,6-dichlorophenol-indophenol
testosterone propionate + 2,6-dichlorophenol-indophenol
17beta-hydroxyandrost-1,4-diene-3-one propionate + reduced 2,6-dichlorophenol-indophenol
(5alpha,17beta)-17-hydroxyandrostan-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
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?
(5alpha,17beta)-17-hydroxyandrostan-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
-
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?
, 4,9(11)-androstadiene-3,17-dione + acceptor
? + reduced acceptor
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?
, 4,9(11)-androstadiene-3,17-dione + acceptor
? + reduced acceptor
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?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + 2,6-dichlorphenolindophenol
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced 2,6-dichlorphenolindophenol
hydrocortisone
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-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + 2,6-dichlorphenolindophenol
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced 2,6-dichlorphenolindophenol
hydrocortisone
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-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
hydrocortisone
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?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
Mycolicibacterium neoaurum DSM 1381
hydrocortisone
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-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
hydrocortisone
-
-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
hydrocortisone
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-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + phenazine methosulfate
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced phenazine methosulfate
hydrocortisone
-
-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + phenazine methosulfate
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced phenazine methosulfate
hydrocortisone
-
-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione acetate + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione acetate + reduced acceptor
hydrocortisone acetate
-
-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione acetate + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione acetate + reduced acceptor
Mycolicibacterium neoaurum DSM 1381
hydrocortisone acetate
-