EC Number   |
Reaction |
Reference |
|---|
   4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
reaction mechanism, detailed overview |
-, 727362 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
reaction mechanism, overview |
727010 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
reaction mechanisms of CPD DNA photolyase and cytochrome DASH, detailed overview |
-, 748854 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
reaction mechanisms of CPD DNA photolyase and cytochrome DASH, detailed overview. Proposed intraprotein electron transfer from W306 to FADH radical is not a part of the normal photolyase photocycle in vivo |
748854 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
reduced anionic flavin adenine dinucleotide (FADH-) is the critical cofactor in DNA photolyase (PL) for the repair of cyclobutane pyrimidine dimers (CPD) in UV-damaged DNA. The initial step involves photoinduced electron transfer from FADH- radical to the CPD. The adenine (Ade) moiety is nearly stacked with the flavin ring, an unusual conformation compared to other FAD-dependent proteins |
748850 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
results support the electron hopping mechanism by which electron transfer from W306 to the flavin is mediated in a three-step electron hopping process (W306 to W359 to W382 to FADH) |
678217 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
substrate/cofactor binding and reaction mechanism, catalytic active site Met397, overview |
727900 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
the DNA repair enzyme recognizes a solvent-exposed cyclobutadipyrimidine as part of its damage recognition mechanism |
728187 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
the reaction is initiated by blue light and proceeds through long-range energy transfer, single electron transfer and enzyme catalysis by a radical mechanism |
33502 |
| 4.1.99.3 | cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
the repair of CPD reveals seven electron-transfer (ET) reactions among ten elementary steps by a cyclic ET radical mechanism through bifurcating ET pathways, a direct tunneling route mediated by the intervening adenine and a two-step hopping path bridged by the intermediate adenine from the cofactor to damaged DNA, through the conserved folded flavin at the active site. Repair photocycle of the PLs and development of a unified repair mechanism for all CPD PLs with the critical, bifurcating electron transfer pathways through the folded flavin cofactor in the conserved active site structure, overview |
-, 746920 |
