EC Number   |
Application |
Reference |
|---|
   3.1.6.2 | analysis |
enzyme hydrolyzes dehydroepiandrosterone 3-sulfate and epiandrosterone 3-sulfate in a urine matrix. Purified arylsulfatase contains only sulfatase activity allowing for the selective hydrolysis of sulfate esters in the presence of glucuronide conjugates. The enzyme can be employed for short three-step chemoenzymatic synthesis of 5alpha-androstane-3beta,17beta-diol 17-glucuronide from epiandrosterone 3-sulfate |
-, 750395 |
| 3.1.6.2 | analysis |
method for the evaluation of aromatase and steryl-sulfatase activites in endometrial tumors using tritium-labeled steroids |
678991 |
| 3.1.6.2 | medicine |
- |
135600, 135601 |
| 3.1.6.2 | medicine |
2-phenylindole sulfamates with antiproliferative activity in breast cancer cells are devoid of estrogenic activity and have the potential for in vivo application as steroid sulfatase inhibitors in the treatment of hormone-dependent breast cancer |
656658 |
| 3.1.6.2 | medicine |
administration of oestrone sulfamate to ovariectomised animal results in 3.5fold increase in the uterine weight. Coadministation of oestrone sulfamate and 667 COUMATE completely blocks enzyme activity and completely abrogates the ability of oestrone sulfamate to stimulate uterine growth |
663843 |
| 3.1.6.2 | medicine |
also associated with multiple sulfatase deficiency |
135595 |
| 3.1.6.2 | medicine |
analysis of enzyme activity and sulfuryl transferase activity in the 55 most frequent human brain tumors incuding glioblastomas, pituitatry adenomas, meningiomas, astrocytomas. Significant differences in enzyme activity among the investigated types of tumors, that do not depend on sex or age of subjects |
681649 |
| 3.1.6.2 | medicine |
benzothiophene sulfates of raloxifene and arzoxifene used as hormone replacement therapeutic agents are hydrolyzed by the enzyme, whereas the raloxifene 4'-phenolic sulfate is resistant. Tissue specific expression of sulfotransferase isoforms and of steroid sulfatase can be important in the inactivation and regeneration of the active form of hormone replacement therapeutic agents |
681646 |
| 3.1.6.2 | medicine |
blocking of dehydroepiandrosterone sulfate sulfatase activity could be prove to be clinically important in oestrogen-dependent tumors in pre-menopausal women |
656370 |
| 3.1.6.2 | medicine |
deficiency in X-linked placental insufficiency and X-linked ichthyosis |
135595, 135602, 135605, 135606, 135622, 135628 |
