Literature summary for 3.1.6.2 extracted from

Chander, S.K.; Purohit, A.; Woo, L.W.; Potter, B.V.; Reed, M.J.
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates (2004), Biochem. Biophys. Res. Commun., 322, 217-222.

Search for more literature for 3.1.6.2

Application

Application	Comment	Organism
medicine	administration of oestrone sulfamate to ovariectomised animal results in 3.5fold increase in the uterine weight. Coadministation of oestrone sulfamate and 667 COUMATE completely blocks enzyme activity and completely abrogates the ability of oestrone sulfamate to stimulate uterine growth	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
667 COUMATE	i.e. 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta(c)chromen-3-yl sulfamate, coadministation of oestrone sulfamate and 667 COUMATE completely blocks enzyme activity and completely abrogates the ability of oestrone sulfamate to stimulate uterine growth	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	enzyme is responsible for the removal of the sulfamoyl group from oestrogen sulfamates	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	ovarectomised animal	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is responsible for the removal of the sulfamoyl group from oestrogen sulfamates	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)