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Results 1 - 3 of 3
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.214drug development RNA interference technology obtains a targeted down-regulation of the endogenous beta1,2-xylosyltransferase (XylT) and alpha1,3-fucosyltransferase (FucT) genes, whereby generating RNAi lines which are stable, viable and do not show any obvious phenotype, thus providing a robust tool for the production of therapeutically relevant glycoproteins in plants with a humanized N -glycan structure 694619
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.214pharmacology the enzyme is a target for rational inhibitor design for medication in the treatment of rheumatoid arthritis 661836
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.214synthesis a KO line lacking two XylT genes and four FucT genes expressing a human IgG2 antibody shows an IgG2 expression level as high as in a control transformant. The IgG glycosylation profile shows no beta(1,2)-xylose or alpha(1,3)-fucose present on the glycosylation moiety. The dominant glycoform is the GnGn structure 756828
Results 1 - 3 of 3