EC Number   |
Application |
Reference |
|---|
    1.1.1.267 | biotechnology |
DXR plays a role in the methyl-D-erythritol 4-phosphate pathway, which is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance and is considered as a target to develop new herbicides and antimicrobial drugs |
699265 |
| 1.1.1.267 | drug development |
1-deoxy-D-xylulose-5-phosphate reductoisomerase in the nonmevalonate isoprene biosynthesis pathway is a target for developing antimalarial drugs |
723812 |
| 1.1.1.267 | drug development |
because the enzyme is absent in humans, DXR is a target for drug discovery |
724346 |
| 1.1.1.267 | drug development |
enzyme DXR is a validated antimicrobial target |
762667 |
| 1.1.1.267 | drug development |
enzyme DXR is an antimicrobial target |
-, 763000 |
| 1.1.1.267 | drug development |
Escherichia coli Dxr represents a valuable model enzyme for the screening for new antimalarial compounds, since work with the Plasmodium falciparum Dxr is associated with considerably high effort due to the instability of this enzyme and the low yield of the available recombinant expression system, no major differences in the IC50 between Escherichia coli Dxr and Plasmodium falciparum Dxr |
697249 |
| 1.1.1.267 | drug development |
the enzyme from Escherichia coli is a valuable target for the development of antimicrobial compounds |
762794 |
| 1.1.1.267 | drug development |
the enzyme from Mycobacterium smegmatis is a valuable target for the development of antimicrobial compounds |
-, 762794 |
| 1.1.1.267 | drug development |
the enzyme is a potential target for antimalarial drug development and chemotherapy |
675038 |
| 1.1.1.267 | drug development |
the enzyme is a target for antibacterial agents and inhibitor design |
672538 |
