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Information on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

for references in articles please use BRENDA:EC1.1.1.267
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IUBMB Comments
The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
1-deoxy-d-xylulose 5-phosphate reductoisomerase, 1-deoxy-d-xylulose-5-phosphate, dxp reductoisomerase, mep synthase, doxp reductoisomerase, deoxyxylulose 5-phosphate reductoisomerase, 2c-methyl-d-erythritol 4-phosphate synthase, rv2870c, doxp-reductoisomerase, pddxr, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
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