EC Number   |
Natural Substrates |
|---|
    1.5.1.8 | L-lysine + 2-oxoglutarate + NADH + H+ |
- |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
- |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
biosynthetic pathway of lysine in yeast and fungi |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
activity of native enzyme is inhibited after modulation, enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding, Ca2+ may be the most important physiological modulator of enzyme activity, it possibly activates through the derepression of an inhibitory domain in vivo |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
saccharopine pathway is the major route of lysine breakdown |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
increase in free lysine concentration in cells decrease enzyme activity through repression of lys1 gene, precursor alpha-aminoadipic-delta-semialdehyde modulates a transcriptional factor that controls transcription of lys1 gene |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
uni-directional activity plays an important role in regulating the catabolic function of alpha-aminoadipidic acid pathway in plants and stems from structure rather than its linkage to saccharopine dehydrogenase EC 1.5.1.9 |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
first step in lysine breakdown in the endosperm during seed development |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
plays essential role in lysine biosynthesis, LKR and SDH are separate polypeptides |
| 1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH |
first and possibly a rate-limiting step in lysine catabolism |
