EC Number   |
Natural Substrates |
|---|
    6.3.4.2 | ATP + UTP + L-glutamine |
- |
| 6.3.4.2 | ATP + UTP + NH3 |
- |
| 6.3.4.2 | more |
CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed |
| 6.3.4.2 | ATP + UTP + glutamine |
CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview |
| 6.3.4.2 | more |
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP |
| 6.3.4.2 | ATP + UTP + NH3 |
CTPS1 is involved in microtubule network formation and/or stabilzation, overview |
| 6.3.4.2 | more |
in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP |
| 6.3.4.2 | more |
key enzyme for biosynthesis of cytosine ribonucleotides |
| 6.3.4.2 | ATP + UTP + NH4+ |
last step in CTP biosynthesis |
| 6.3.4.2 | more |
rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred |
