EC Number   |
Natural Substrates |
|---|
   1.21.99.4 | L-thyroxine + AH2 |
idothyronine 5'-deiodinase type I |
| 1.21.99.4 | L-thyroxine + AH2 |
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine |
| 1.21.99.4 | L-thyroxine + AH2 |
isoenzyme Dio1 |
| 1.21.99.4 | L-thyroxine + AH2 |
activation and deactivation of thyroid hormone |
| 1.21.99.4 | L-thyroxine + electron acceptor |
the enzyme is regulated at the pretranslational level |
| 1.21.99.4 | L-thyroxine + reduced acceptor |
- |
| 1.21.99.4 | more |
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway |
| 1.21.99.4 | more |
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview |
