show all | hide all No of entries

Information on EC - thyroxine 5'-deiodinase

for references in articles please use BRENDA:EC1.21.99.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
deiodinase, type 2 deiodinase, iodothyronine 5'-deiodinase, type 3 deiodinase, type 2 iodothyronine deiodinase, type 1 deiodinase, type i iodothyronine deiodinase, type ii iodothyronine deiodinase, type i iodothyronine 5'-deiodinase, type 1 iodothyronine deiodinase, more
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
show the reaction diagram