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EC Number
Inhibitors
Commentary
Structure
6.2.1.5
2-oxoglutarate
-
6.2.1.5
2-oxoglutarate
no inhibition
6.2.1.5
5,5'-dithiobis(2-nitrobenzoate)
-
6.2.1.5
acetate
-
6.2.1.5
ADP
-
6.2.1.5
ADP
adenosine 5ยด-tetraphosphate formation
6.2.1.5
AMP
-
6.2.1.5
ATP
-
6.2.1.5
ATP
above 10 mM
6.2.1.5
Borohydride
inactivation, in the presence of acetyl-CoA causes near-complete loss of enzyme activity consistent with the reduction of the glutamyl-CoA thioester intermediate to 5-hydroxynorvaline, in absence of acetyl-CoA only partial inactivation, 71% activity relative to a control, occurs
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