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EC Number
Inhibitors
Commentary
Structure
5.6.1.5
ADP
-
5.6.1.5
alpha,beta-methyleneadenosine 5'-triphosphate
-
5.6.1.5
ATP
increasing ATP beyond the optimal range is inhibitory
5.6.1.5
ATPgammaS
inhibits 26S proteasome ATPase activity over the same concentration range in which it stimulates peptidase activity
5.6.1.5
EDTA
-
5.6.1.5
hemin
inhibitor of proteasome 19S ATPases
5.6.1.5
lactacystin
-
5.6.1.5
lactacystin
specific inhibitor of the eukaryotic proteasome
5.6.1.5
more
alkylation of Sug1 or Sug2 leads to inhibition of 26S peptidase activity by different mechanisms
5.6.1.5
more
a decline in proteasome activity with the aging process is shown
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