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Information on EC 5.6.1.5 - proteasome ATPase

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EC Tree
IUBMB Comments
Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
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Word Map
  • 5.6.1.5
  • atpases
  • ubiquitin-proteasome
  • hexameric
  • disassembly
  • misfolded
  • subcomplexes
  • polyubiquitinated
  • machine
  • hslu
  • ubiquitin-dependent
  • non-atpase
  • er-associated
  • torsina
  • multisubunit
  • ubiquitin-like
  • reticulum-associated
  • escrts
  • valosin-containing
  • dystonia
  • proteasome-mediated
  • deubiquitinase
  • escrt-iii
  • multivesicular
  • zellweger
  • signalosome
  • cryo-em
  • adp-bound
  • proteotoxic
  • spastin
  • peroxins
  • ring-shaped
  • deubiquitylating
  • immunoproteasome
  • retrotranslocation
  • proteasome-associated
  • katanin
  • medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
=
+
+
unfolded polypeptide
Synonyms
19S ATPase, 19S ATPase proteasome subunit, 19S proteasomal ATPase, 19S proteasome, 19S proteasome ATPase, 19S regulatory particle, 19S RP, 19S Rpt subunit, 20S proteasome, 26S protease regulatory subunit 10B, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide
show the reaction diagram
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