EC Number   |
Activating Compound |
Reference |
|---|
   7.2.2.19 | ADP |
activates NTPase activity of the enzyme |
685080 |
| 7.2.2.19 | H+ |
- |
700594 |
| 7.2.2.19 | indomethacin |
activates by 65% |
697414 |
| 7.2.2.19 | L-phenylalanine |
80 mM L-phenylalanine stimulates enzyme activity |
750685 |
| 7.2.2.19 | L-tryptophan |
50 mM L-tryptophan stimulates enzyme activity |
750685 |
| 7.2.2.19 | more |
no activation by DFU, i.e. 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2-(5H)-furanone |
697414 |
| 7.2.2.19 | more |
no protective effect during C12E8-solubilization of gastric H/K-ATPase by choline |
674353 |
| 7.2.2.19 | more |
Sp1 protein, a member of the Sp/Krüppel-like factor transcription factors. Sp1, but not Sp3, binds to this promoter region of the HKalpha2 gene in mIMCD3 cells in vivo and transactivates the gene expression. siRNA knockdown of Sp1 inhibits endogenous HKalpha2 mRNA expression |
695503 |
| 7.2.2.19 | more |
upregulation of HKalpha2 protein is a robust phenomenon, induced by multiple means of decreasing extracellular pH. Critical role for PKA in the maturation and function of the H+-K+-ATPase alpha-subunit and H+-ATPase, a mechanism that involves phosphorylation at key serine residues |
718552 |
| 7.2.2.19 | NH4+ |
20 mM, increases activity by about 4.5fold |
654605 |
