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Version 2014-12-22
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Details for nuclear pore linkers
Gene ontology ID
GO:0044612
Definition
A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)
Synonyms
1. Nic96 complex
2. Nup82 complex
References
1. GOC: dgf
2. PMID 18046406
3. PMID 19524430
4. PMID 20947011
5. PMID 22419078
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