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Gene ontology
Version 2014-12-22
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Details for cytoplasmic exosome (RNase complex)
Gene ontology ID
GO:0000177
Definition
A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured
Synonyms
1. cytoplasmic exosome (ribonuclease complex)
2. cytoplasmic exosome multienzyme ribonuclease complex
3. prokaryotic exosome multienzyme ribonuclease complex
References
1. PMID 17174896
2. PMID 20531386
3. PMID 26726035
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