Details for Bre1-Rad6 ubiquitin ligase complex
Gene ontology ID
GO:1990302
Definition
A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
Synonyms
1. Bre1-Rad6 complex
References
1. GOC: bhm
2. PMID 195314753. IntAct: EBI-9102228
Legend
![](./ontology/inc/tree/images/is_a.png)
is an element of the parent element
![](./ontology/inc/tree/images/part_of.png)
is a part of the parent element
![](./ontology/inc/tree/images/rel.png)
is related to the parent element
![](./ontology/inc/tree/images/der.png)
derives from the parent element
![](./ontology/inc/tree/images/tissue_branch.png)
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![](./ontology/inc/tree/images/brenda_branch.png)
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![](./ontology/inc/tree/images/localization_branch.png)
at least 1 tissue/ enzyme/ localization link in this branch
![](./ontology/inc/tree/images/tissue.png)
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![](./ontology/inc/tree/images/brenda.png)
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![](./ontology/inc/tree/images/localization.png)
tissue/ enzyme/ localization link to BRENDA
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Gene ontology