Details for mitotic spindle assembly checkpoint MAD1-MAD2 complex
Gene ontology ID
GO:1990728
Definition
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex
Comment
An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
Synonyms
1. MAD1-MAD2 complex
References
1. GOC: bhm
2. PMID 120065013. PMID 228987744. IntAct: EBI-10691260
5. IntAct: EBI-10705307
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is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA
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