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Gene ontology
Version 2014-12-22
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Details for RNA NAD-cap (NMN-forming) hydrolase activity
Gene ontology ID
GO:0110153
Definition
Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
Comment
This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.
References
1. GOC: sp
2. PMID 25533955
3. PMID 31101919
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
hydrolase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides is a
RNA NAD-cap (NMN-forming) hydrolase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides is a
5'-acylphosphoadenosine hydrolase activity is a
8-oxo-deoxyadenine diphosphate phosphatase activity is a
8-oxo-dGTP phosphohydrolase activity is a
acylphosphatase activity is a
cyclic-GMP-AMP hydrolase activity is a
dATP phosphohydrolase activity is a
dCTP phosphohydrolase activity is a
dGTP phosphohydrolase activity is a
dihydroneopterin monophosphate phosphatase activity is a
dTTP phosphohydrolase activity is a
dUTP phosphohydrolase activity is a
GTP phosphohydrolase activity is a
ITPase activity is a
nucleoside phosphoacylhydrolase activity is a
phosphocholine hydrolase activity is a
pyrophosphatase activity is a
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity is a
5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity is a
adenosine-tetraphosphatase activity is a
ADP-ribose diphosphatase activity is a
ADP-sugar diphosphatase activity is a
CDP-diacylglycerol diphosphatase activity is a
CDP-glycerol diphosphatase activity is a
CoA pyrophosphatase activity is a
deoxynucleoside-diphosphatase activity is a
diacylglycerol diphosphate phosphatase activity is a
dihydroneopterin triphosphate pyrophosphohydrolase activity is a
diphosphoinositol-polyphosphate diphosphatase activity is a
dolichyldiphosphatase activity is a
endopolyphosphatase activity is a
exopolyphosphatase activity is a
GDP-mannose hydrolase activity is a
guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity is a
inorganic diphosphatase activity is a
inositol bisdiphosphate tetrakisphosphate diphosphatase activity is a
inositol diphosphate pentakisphosphate diphosphatase activity is a
inositol diphosphate tetrakisphosphate diphosphatase activity is a
m7G(5')pppN diphosphatase activity is a
nucleoside-diphosphatase activity is a
nucleoside-triphosphatase activity is a
ATPase activity is a
CTPase activity is a
GTPase activity is a
motor activity is a
thiamin-triphosphatase activity is a
thymidine-triphosphatase activity is a
nucleoside-triphosphate diphosphatase activity is a
nucleotide diphosphatase activity is a
oligosaccharide-diphosphodolichol diphosphatase activity is a
phosphoribosyl-ATP diphosphatase activity is a
RNA pyrophosphohydrolase activity is a
triphosphatase activity is a
UDP-2,3-diacylglucosamine hydrolase activity is a
UDP-sugar diphosphatase activity is a
undecaprenyl-diphosphatase activity is a
RNA NAD-cap (NAD-forming) hydrolase activity is a
RNA NAD-cap (NMN-forming) hydrolase activity is a
trimetaphosphatase activity is a
hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a