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Version 2014-12-22
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Details for second spliceosomal transesterification activity
Gene ontology ID
Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure
1. 3'-splice site cleavage, exon ligation
2. lariat formation, 5'-splice site cleavage
1. GOC: krc
2. ISBN 0879695897
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