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Version 2014-12-22
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Details for thiopurine S-methyltransferase activity
2.1.1.67
Gene ontology ID
GO:0008119
Definition
Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether
Synonyms
1. 6-thiopurine transmethylase activity
2. mercaptopurine methyltransferase activity
3. S-adenosyl-L-methionine:thiopurine S-methyltransferase activity
4. thiopurine methyltransferase activity
5. TPMT
References
1. EC 2.1.1.67
2. MetaCyc THIOPURINE-S-METHYLTRANSFERASE-RXN
3. Reactome: R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP"
4. Reactome: R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP"
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