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Gene ontology
Version 2014-12-22
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Details for aconitate hydratase activity
4.2.1.3
Gene ontology ID
GO:0003994
Definition
Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate
Comment
This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'.
Synonyms
1. aconitase activity
2. cis-aconitase activity
3. citrate hydro-lyase activity
4. citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
5. citrate(isocitrate) hydro-lyase activity
References
1. EC 4.2.1.3
2. GOC: pde
3. GOC: vw
4. Reactome: R-HSA-450975 "isocitrate <=> citrate"
5. Reactome: R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT"
6. Reactome: R-HSA-70971 "citrate <=> isocitrate"
7. RHEA: 10336
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
lyase activity is a
carbon-oxygen lyase activity is a
hydro-lyase activity is a
aconitate hydratase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity is a
alkylmercury lyase activity is a
carbon phosphorus lyase activity is a
carbon-carbon lyase activity is a
carbon-halide lyase activity is a
carbon-nitrogen lyase activity is a
carbon-oxygen lyase activity is a
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity is a
carbon-oxygen lyase activity, acting on phosphates is a
carbon-oxygen lyase activity, acting on polysaccharides is a
carboxymethyloxysuccinate lyase activity is a
hydro-lyase activity is a
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity is a
(R)-2-methylmalate dehydratase activity is a
(S)-2-methylmalate dehydratase activity is a
(S)-norcoclaurine synthase activity is a
1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity is a
1,5-anhydro-D-fructose dehydratase activity is a
14betaH-scalarane-17alpha-19-diol synthase activity is a
16-alpha-hydroxyprogesterone dehydratase activity is a
17(E)-cheilanthenediol synthase activity is a
2,4,4-trimethylpent-2-enoyl-CoA hydratase activity is a
2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity is a
2-dehydro-3-deoxy-L-arabinonate dehydratase activity is a
2-hydroxydec-2,4-diene-1,10-dioate hydratase activity is a
2-hydroxyeriodictyol 6C-glucoside dehydratase activity is a
2-hydroxyglutaryl-CoA dehydratase activity is a
2-hydroxyhexa-2,4-dienoate hydratase activity is a
2-hydroxyisobutyrate dehydratase activity is a
2-hydroxyisoflavanone dehydratase activity is a
2-hydroxynaringenin-6C-glucoside dehydratase activity is a
2-keto-3-deoxygalactonate aldolase activity is a
2-methylcitrate dehydratase activity is a
2-methylhex-2-enoyl-CoA hydratase activity is a
2-methylisocitrate dehydratase activity is a
2-oxo-hept-3-ene-1,7-dioate hydratase activity is a
2-oxopent-4-enoate hydratase activity is a
3-cyanoalanine hydratase activity is a
3-dehydroquinate dehydratase activity is a
3-dehydroshikimate dehydratase activity is a
3-hydroxy-arachidoyl-CoA dehydratase activity is a
3-hydroxy-behenoyl-CoA dehydratase activity is a
3-hydroxy-cerotoyl-CoA dehydratase activity is a
3-hydroxy-lignoceroyl-CoA dehydratase activity is a
3-hydroxyacyl-CoA dehydratase activity is a
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity is a
3-hydroxybutyryl-CoA dehydratase activity is a
3-hydroxypropionyl-CoA dehydratase activity is a
3-isopropylmalate dehydratase activity is a
3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity is a
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity is a
3R-hydroxyacyl-CoA dehydratase activity is a
4-alpha-hydroxytetrahydrobiopterin dehydratase activity is a
4-hydroxy-tetrahydrodipicolinate synthase activity is a
4-hydroxybutanoyl-CoA dehydratase activity is a
4-methyloct-2-enoyl-CoA hydratase activity is a
4-oxalmesaconate hydratase activity is a
5-alpha-hydroxysteroid dehydratase activity is a
5-chloro-2-oxopent-4-enoate hydratase activity is a
5-dehydro-4-deoxyglucarate dehydratase activity is a
6-carboxy-5,6,7,8-tetrahydropterin synthase activity is a
acetylene hydratase activity is a
acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate is a
acetylenecarboxylate hydratase activity, producing 3-oxopropanoate is a
aconitate hydratase activity is a
ADP-dependent NAD(P)H-hydrate dehydratase activity is a
aldos-2-ulose dehydratase activity is a
allene oxide synthase activity is a
altronate dehydratase activity is a
arabinonate dehydratase activity is a
arogenate dehydratase activity is a
ATP-dependent NAD(P)H-hydrate dehydratase activity is a
bile-acid 7alpha-dehydratase activity is a
carbonate dehydratase activity is a
carnitine dehydratase activity is a
CDP-glucose 4,6-dehydratase activity is a
colneleate synthase activity is a
colnelenate synthase activity is a
copal-8-ol diphosphate synthase activity is a
crotonyl-CoA hydratase activity is a
cyanamide hydratase activity is a
cyanide hydratase activity is a
cyclohex-1-ene-1-carboxyl-CoA hydratase activity is a
cyclohexa-1,5-dienecarbonyl-CoA hydratase activity is a
cyclohexyl-isocyanide hydratase activity is a
cystathionine beta-synthase activity is a
D(-)-tartrate dehydratase activity is a
D-fuconate dehydratase activity is a
dihydroxy-acid dehydratase activity is a
dimethylmaleate hydratase activity is a
dTDP-glucose 4,6-dehydratase activity is a
E-phenylitaconyl-CoA hydratase activity is a
ectoine synthase activity is a
endosulfan diol hydrolyase (cyclizing) activity is a
enoyl-CoA hydratase activity is a
fumarate hydratase activity is a
galactarate dehydratase activity is a
galactonate dehydratase activity is a
GDP-mannose 4,6-dehydratase activity is a
glucarate dehydratase activity is a
gluconate dehydratase activity is a
glycerol dehydratase activity is a
homoaconitate hydratase activity is a
hydroperoxide dehydratase activity is a
hydroperoxy icosatetraenoate dehydratase activity is a
imidazoleglycerol-phosphate dehydratase activity is a
isohexenylglutaconyl-CoA hydratase activity is a
itaconyl-CoA hydratase activity is a
kievitone hydratase activity is a
L(+)-tartrate dehydratase activity is a
L-altrarate dehydratase activity is a
L-arabinonate dehydratase activity is a
L-erythro-3-methylmalyl-CoA dehydratase activity is a
L-fuconate dehydratase activity is a
L-rhamnonate dehydratase activity is a
L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity is a
lactoyl-CoA dehydratase activity is a
limonene 8-hydratase activity is a
long-chain-enoyl-CoA hydratase activity is a
lupan-3beta,20-diol synthase activity is a
maleate hydratase activity is a
mannonate dehydratase activity is a
menth-2-enone hydratase activity is a
mesaconyl-CoA hydratase activity is a
methylglutaconyl-CoA hydratase activity is a
methylthioribulose 1-phosphate dehydratase activity is a
monocyclic sesterterpenediol synthase activity is a
myo-inosose-2 dehydratase activity is a
naphthyl-2-methylene-succinyl-CoA lyase activity is a
nitrile hydratase activity is a
O-succinylbenzoate synthase activity is a
octopamine dehydratase activity is a
oleate hydratase activity is a
OPC4-trans-2-enoyl-CoA hydratase activity is a
OPC6-trans-2-enoyl-CoA hydratase activity is a
OPC8-trans-2-enoyl-CoA hydratase activity is a
peregrinol diphosphate synthase activity is a
perillyl-CoA hydratase activity is a
phaseollidin hydratase activity is a
phosphogluconate dehydratase activity is a
phosphopyruvate hydratase activity is a
porphobilinogen synthase activity is a
prephenate dehydratase activity is a
propanediol dehydratase activity is a
protoaphin-aglucone dehydratase (cyclizing) activity is a
pterin-4alpha-carbinolamine dehydratase activity is a
pyrazolylalanine synthase activity is a
retinol dehydratase activity is a
scalarane-17alpha-19-diol synthase activity is a
scytalone dehydratase activity is a
selenocystathionine beta-synthase activity is a
synephrine dehydratase activity is a
trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity is a
trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity is a
trans-feruloyl-CoA hydratase activity is a
trans-L-3-hydroxyproline dehydratase activity is a
trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity is a
UDP-glucose 4,6-dehydratase activity is a
urocanate hydratase activity is a
uroporphyrinogen-III synthase activity is a
very-long-chain 3-hydroxyacyl-CoA dehydratase activity is a
xylonate dehydratase activity is a
isochorismate pyruvate lyase activity is a
O-acetylhomoserine sulfhydrylase activity is a
versicolorin B synthase activity is a
carbon-sulfur lyase activity is a
cobalt-precorrin-5A acetaldehyde-lyase activity is a
ferrochelatase activity is a
indoleacetaldoxime dehydratase activity is a
phosphorus-oxygen lyase activity is a
sirohydrochlorin cobaltochelatase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a