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Gene ontology
Version 2014-12-22
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Details for DNA-N1-methyladenine dioxygenase activity
Gene ontology ID
GO:0043734
Definition
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde
Synonyms
1. AlkB
2. alpha-ketoglutarate-dependent dioxygenase
References
1. PMID 19786499
2. Reactome: R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"
3. Reactome: R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
methylgalactoside transport is a
metabolic process is a
N-acetylglucosamine metabolic process is a
amylopectin metabolic process is a
oxidation-reduction process is a
oxidoreductase activity part of
dioxygenase activity is a
2-oxoglutarate-dependent dioxygenase activity is a
DNA-N1-methyladenine dioxygenase activity is a
5-epi-aristolochene-1,3-dihydroxylase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
iodide oxidation is a
oxidative deethylation is a
oxidoreductase activity part of
1,1,1-trichloroethane reductive dehalogenase activity is a
1,1,2-trichloroethene reductive dehalogenase activity is a
1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity is a
1,1-dichloroethane reductive dehalogenase activity is a
1,2-dichloroethene reductive dehalogenase activity is a
2,4-dichloroaniline reductive dehalogenase activity is a
2,4-dichlorophenoxyacetate dehalogenase activity is a
2,5-dichlorohydroquinone reductive dehalogenase activity is a
2-chloro-N-isopropylacetanilide reductive dehalogenase activity is a
2-octaprenylphenol hydroxylase activity is a
2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity is a
3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity is a
3,3',5-tribromobisphenol A reductive dehalogenase activity is a
3,3'-dibromobisphenol A reductive dehalogenase activity is a
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity is a
3-monobromobisphenol A reductive dehalogenase activity is a
alpha-ketoacid dehydrogenase activity is a
arsenate reductase activity is a
chlorate reductase activity is a
chromate reductase activity is a
crotonyl-CoA reductase activity is a
delta1-piperideine-6-carboxylate dehydrogenase activity is a
dihydronicotinamide riboside quinone reductase activity is a
dihydropterin oxidase activity is a
dimethylarsinate reductase activity is a
dioxygenase activity is a
1,2-dihydroxynaphthalene dioxygenase activity is a
2-oxoglutarate-dependent dioxygenase activity is a
(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity is a
(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity is a
1-ethyladenine demethylase activity is a
2'-deoxymugineic-acid 2'-dioxygenase activity is a
2'-deoxymugineic-acid 3-dioxygenase activity is a
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity is a
2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity is a
4-chloro-2-methylphenoxyacetate oxygenase activity is a
4-coumaroyl 2'-hydroxylase activity is a
5-formylcytosine dioxygenase activity is a
5-hydroxymethylcytosine dioxygenase activity is a
6-beta-hydroxyhyoscyamine epoxidase activity is a
anthocyanidin synthase activity is a
clavaminate synthase activity is a
codeine O-demethylase activity is a
deacetoxycephalosporin-C hydroxylase activity is a
deoxyuridine 1'-dioxygenase activity is a
deoxyuridine 2'-dioxygenase activity is a
desacetoxyvindoline 4-hydroxylase activity is a
DNA-N1-methyladenine dioxygenase activity is a
FR-33289 synthase activity is a
GA20 2,3-desaturase activity is a
GA5 2,3 epoxidase activity is a
GA5 3beta-hydroxylase activity is a
gamma-butyrobetaine dioxygenase activity is a
gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin 2-beta-dioxygenase activity is a
gibberellin 20-oxidase activity is a
gibberellin 3-beta-dioxygenase activity is a
gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) is a
gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) is a
gibberellin A12,oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A13,oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A17,oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A25 hydroxylase activity is a
gibberellin A25,oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A28,oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) is a
gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity is a
gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity is a
gibberellin-44 dioxygenase activity is a
hyoscyamine (6S)-dioxygenase activity is a
hypophosphite dioxygenase activity is a
hypoxia-inducible factor-asparagine oxygenase activity is a
L-gamma-glutamyl-L-propargylglycine hydroxylase activity is a
leucocyanidin oxygenase activity is a
methylcytosine dioxygenase activity is a
mugineic-acid 3-dioxygenase activity is a
N1-methyladenine demethylase activity is a
N3-methylcytosine demethylase activity is a
naringenin 3-dioxygenase activity is a
oripavine 6-O-demethylase activity is a
peptide-aspartate beta-dioxygenase activity is a
peptidyl-arginine 3-dioxygenase activity is a
peptidyl-asparagine 3-dioxygenase activity is a
peptidyl-histidine dioxygenase activity is a
peptidyl-lysine 3-dioxygenase activity is a
peptidyl-lysine 4-dioxygenase activity is a
peptidyl-lysine 5-dioxygenase activity is a
phytanoyl-CoA dioxygenase activity is a
proline 3-hydroxylase activity is a
sulfonate dioxygenase activity is a
taurine dioxygenase activity is a
thebaine 6-O-demethylase activity is a
thebane O-demethylase activity is a
thymine dioxygenase activity is a
trimethyllysine dioxygenase activity is a
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity is a
3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity is a
3-butenylglucosinolate 2-hydroxylase activity is a
alpha-ketoglutarate-dependent xanthine dioxygenase activity is a
DDT 2,3-dioxygenase activity is a
DOPA dioxygenase activity is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen is a
epoxyqueuosine reductase activity is a
fatty acid alpha-hydroxylase activity is a
geranylgeranyl reductase activity is a
glycyl-radical enzyme activating activity is a
heme-copper terminal oxidase activity is a
hydroxymethylbutenyl pyrophosphate reductase activity is a
malolactic enzyme activity is a
monooxygenase activity is a
2-hydroxyisobutyrate 3-monooxygenase activity is a
2-hydroxypyridine 5-monooxygenase activity is a
20-aldehyde-leukotriene B4 20-monooxygenase activity is a
3-hydroxybenzoate 2-monooxygenase activity is a
4-chlorophenoxyacetate monooxygenase activity is a
4-ketotorulene 3-hydroxylase activity is a
4-methoxybenzoate monooxygenase (O-demethylating) activity is a
4-nitrocatechol 4-monooxygenase activity is a
adonirubin 3-hydroxylase activity is a
all-trans retinoic acid 18-hydroxylase activity is a
alpha-pinene monooxygenase activity is a
ammonia monooxygenase activity is a
androst-4-ene-3,17-dione monooxygenase activity is a
arachidonic acid monooxygenase activity is a
beta-carotene 3-hydroxylase activity is a
beta-cryptoxanthin hydroxylase activity is a
canthaxanthin 3-hydroxylase activity is a
carotene beta-ring hydroxylase activity is a
carotene epsilon hydroxylase activity is a
coumarin 7-hydroxylase activity is a
deoxyhypusine monooxygenase activity is a
dibenzothiophene-5,5-dioxide monooxygenase activity is a
echinenone 3-hydroxylase activity is a
estradiol 6-beta-monooxygenase activity is a
eupatolide synthase activity is a
fatty acid in-chain hydroxylase activity is a
ferulate 5-hydroxylase activity is a
germacrene A hydroxylase activity is a
jasmonoyl-isoleucine-12-hydroxylase activity is a
linalool 8-monooxygenase activity is a
linoleic acid epoxygenase activity is a
luciferin monooxygenase activity is a
methyl tertiary butyl ether 3-monooxygenase activity is a
naphthalene hydroxylase activity is a
nitrilotriacetate monooxygenase activity is a
ornithine N5-monooxygenase activity is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen is a
anthranilate 3-monooxygenase activity is a
glyceryl-ether monooxygenase activity is a
mandelate 4-monooxygenase activity is a
phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity is a
phenylalanine 4-monooxygenase activity is a
tryptophan 5-monooxygenase activity is a
tyrosine 3-monooxygenase activity is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is a
p-coumarate 3-hydroxylase activity is a
phylloquinone monooxygenase (2,3-epoxidizing) activity is a
progesterone 11-alpha-monooxygenase activity is a
progesterone monooxygenase activity is a
retinoic acid 4-hydroxylase activity is a
secalciferol 1-monooxygenase activity is a
steroid 9-alpha-monooxygenase activity is a
steroid hydroxylase activity is a
tert-butanol 2-monooxygenase activity is a
testosterone 16-beta-hydroxylase activity is a
thalianol hydroxylase activity is a
thiophene-2-carbonyl-CoA monooxygenase activity is a
tryptamine 4-monooxygenase activity is a
vitamin D 23-hydroxylase activity is a
vitamin D 24-hydroxylase activity is a
vitamin D 25-hydroxylase activity is a
NADPH-adrenodoxin reductase activity is a
NADPH:sulfur oxidoreductase activity is a
ortho-trichlorophenol reductive dehalogenase activity is a
oxidoreductase activity, acting on a heme group of donors is a
oxidoreductase activity, acting on a sulfur group of donors is a
oxidoreductase activity, acting on CH or CH2 groups is a
oxidoreductase activity, acting on CH-OH group of donors is a
oxidoreductase activity, acting on diphenols and related substances as donors is a
oxidoreductase activity, acting on halogen in donors is a
oxidoreductase activity, acting on hydrogen as donor is a
oxidoreductase activity, acting on iron-sulfur proteins as donors is a
oxidoreductase activity, acting on NAD(P)H is a
oxidoreductase activity, acting on other nitrogenous compounds as donors is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is a
oxidoreductase activity, acting on peroxide as acceptor is a
oxidoreductase activity, acting on phosphorus or arsenic in donors is a
oxidoreductase activity, acting on reduced flavodoxin as donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is a
oxidoreductase activity, acting on superoxide radicals as acceptor is a
oxidoreductase activity, acting on the aldehyde or oxo group of donors is a
oxidoreductase activity, acting on the CH-CH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors is a
oxidoreductase activity, acting on the CH-NH2 group of donors is a
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond is a
oxidoreductase activity, oxidizing metal ions is a
oxygen evolving activity is a
perchlorate reductase activity is a
phthalate dioxygenase reductase activity is a
pyrogallol hydroxytransferase activity is a
reduced coenzyme F420 dehydrogenase activity is a
reduced coenzyme F420 oxidase activity is a
reduced coenzyme F420:quinone oxidoreductase activity is a
selenate reductase activity is a
sphingosine hydroxylase activity is a
steroid dehydrogenase activity is a
sulfur oxygenase reductase activity is a
sulfur reductase activity is a
tetrachloroethene reductive dehalogenase activity is a
tetrahydrothiophene 1-oxide reductase activity is a
thyroxine 5'-deiodinase activity is a
thyroxine 5-deiodinase activity is a
trimethylarsine oxidase activity is a
tyramine-beta hydroxylase activity is a
uracil oxygenase activity is a
vinyl chloride reductive dehalogenase activity is a
violaxanthin de-epoxidase activity is a
thioredoxin reduction is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a