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Gene ontology
Version 2014-12-22
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Details for methotrexate binding
Gene ontology ID
GO:0051870
Definition
Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA
References
1. GOC: nln
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