Literature summary for 7.6.2.4 extracted from

Iwashita, S.; Tsuchida, M.; Tsukuda, M.; Yamashita, Y.; Emi, Y.; Kida, Y.; Komori, M.; Kashiwayama, Y.; Imanaka, T.; Sakaguchi, M.
Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70 (2010), J. Biochem., 147, 581-590.

Search for more literature for 7.6.2.4

Cloned(Commentary)

Cloned (Comment)	Organism
using transient transfection of COS cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	full-length PMP70 molecule is clearly located in the endoplasmic reticulum in the absence of the N-terminal 80-segment, even when multiple peroxisome-targeting signals are retained	Homo sapiens
additional information	when the N-terminal 80 amino acid residue (N80)-segment preceding transmembrane segment (TM) 1 is deleted and the TM1-TM2 region is fused to EGFP, the TM1 segment induces endoplasmic reticulum-targeting and integration in COS cells	Homo sapiens
additional information	when the N-terminal 80-segment is fused to EGFP, the fusion protein is targeted to the outer mitochondrial membrane	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	when the N-terminal 80 amino acid residue (N80)-segment preceding transmembrane segment (TM) 1 is deleted and the TM1-TM2 region is fused to EGFP, the TM1 segment induces endoplasmic reticulum-targeting	Homo sapiens	5783	-
mitochondrial outer membrane	when the N-terminal 80-segment is fused to EGFP, the fusion protein is targeted to the outer mitochondrial membrane	Homo sapiens	5741	-
peroxisome	when both the N-terminal 80-segment and the following TM1-TM2 region are present, the fusion protein locates exclusively to the peroxisome	Homo sapiens	5777	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
ABCD3	-	Homo sapiens
PMP70	-	Homo sapiens

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Release 2023.1 (January 2023)