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Literature summary for 7.6.2.4 extracted from

  • Di Benedetto, R.; Denti, M.A.; Salvati, S.; Sanchez, M.; Attorri, L.; David, G.; Di Biase, A.
    RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function (2008), Neurochem. Int., 52, 1106-1113.
    View publication on PubMed
Search for more literature for 7.6.2.4

Application

Application Comment Organism
medicine the finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential clinical relevance Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
siRNA RNAi technique is used to knockdown the ABCD3 gene encoding PMP70 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisomal membrane
-
 Rattus norvegicus 5778
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + fatty acyl CoA/cis Rattus norvegicus
-
 ADP + phosphate + fatty acyl CoA/trans
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glial cell C6 glial cell Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + fatty acyl CoA/cis
-
 Rattus norvegicus ADP + phosphate + fatty acyl CoA/trans
-
 ?

Synonyms

Synonyms Comment Organism
fatty-acyl-CoA-transporting ATPase
-
 Rattus norvegicus
PMP70
-
 Rattus norvegicus