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show all sequences of 7.3.2.7

ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite

Hemmingsson, O.; Zhang, Y.; Still, M.; Naredi, P.; Cancer Chemother. Pharmacol. 63, 491-499 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
transfection of T-289 melanoma cells with either ASNA1 sense or ASNA1 antisense constructs, expression analysis
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
T-289 clones with siRNA decreased ASNA1 expression exhibit 51% longer doubling times than wild-type T-289 cells. After exposure to cisplatin, ASNA1 downregulated cells display a significant increase in apoptosis. The cisplatin IC50 in ASNA1 underexpressing cells is 41.7% of the IC50 for wild-type cells, and the arsenite IC50 is 59.9% of wild-type IC50. Phenotypes, overview
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + H2O + arsenite/in
Homo sapiens
-
ADP + phosphate + arsenite/out
-
-
?
ATP + H2O + cisplatin/in
Homo sapiens
-
ADP + phosphate + cisplatin/out
-
-
?
additional information
Homo sapiens
ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite. ASNA1 is also an essential ATPase for the insertion of tail-anchored proteins into endoplasmic reticulum membranes and a regulator of insulin secretion. ASNA1 expression is necessary for growth.
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O43681
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
melanoma cell
-
Homo sapiens
-
T-289 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + arsenite/in
-
697072
Homo sapiens
ADP + phosphate + arsenite/out
-
-
-
?
ATP + H2O + cisplatin/in
-
697072
Homo sapiens
ADP + phosphate + cisplatin/out
-
-
-
?
additional information
ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite. ASNA1 is also an essential ATPase for the insertion of tail-anchored proteins into endoplasmic reticulum membranes and a regulator of insulin secretion. ASNA1 expression is necessary for growth.
697072
Homo sapiens
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
transfection of T-289 melanoma cells with either ASNA1 sense or ASNA1 antisense constructs, expression analysis
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
T-289 clones with siRNA decreased ASNA1 expression exhibit 51% longer doubling times than wild-type T-289 cells. After exposure to cisplatin, ASNA1 downregulated cells display a significant increase in apoptosis. The cisplatin IC50 in ASNA1 underexpressing cells is 41.7% of the IC50 for wild-type cells, and the arsenite IC50 is 59.9% of wild-type IC50. Phenotypes, overview
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + H2O + arsenite/in
Homo sapiens
-
ADP + phosphate + arsenite/out
-
-
?
ATP + H2O + cisplatin/in
Homo sapiens
-
ADP + phosphate + cisplatin/out
-
-
?
additional information
Homo sapiens
ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite. ASNA1 is also an essential ATPase for the insertion of tail-anchored proteins into endoplasmic reticulum membranes and a regulator of insulin secretion. ASNA1 expression is necessary for growth.
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
melanoma cell
-
Homo sapiens
-
T-289 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + H2O + arsenite/in
-
697072
Homo sapiens
ADP + phosphate + arsenite/out
-
-
-
?
ATP + H2O + cisplatin/in
-
697072
Homo sapiens
ADP + phosphate + cisplatin/out
-
-
-
?
additional information
ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite. ASNA1 is also an essential ATPase for the insertion of tail-anchored proteins into endoplasmic reticulum membranes and a regulator of insulin secretion. ASNA1 expression is necessary for growth.
697072
Homo sapiens
?
-
-
-
-
Other publictions for EC 7.3.2.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Yang
Arsenic binding and transfer b ...
Escherichia coli
Biochemistry
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3658-3666
2010
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The 1.4 A crystal structure of ...
Saccharomyces cerevisiae
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719612
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Functional promiscuity of homo ...
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697072
Hemmingsson
ASNA1, an ATPase targeting tai ...
Homo sapiens
Cancer Chemother. Pharmacol.
63
491-499
2009
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Ruan
Characterization of the metall ...
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392-402
2008
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696278
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Caenorhabditis elegans express ...
Caenorhabditis elegans
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687482
Lin
ArsD: an As(III) metallochaper ...
Escherichia coli
J. Bioenerg. Biomembr.
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453-458
2007
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687554
Lin
ArsD residues Cys12, Cys13, an ...
Escherichia coli
J. Biol. Chem.
282
16783-16791
2007
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669530
Ruan
Cys-113 and Cys-422 form a hig ...
Escherichia coli, Escherichia coli plasmid R773
J. Biol. Chem.
281
9925-9934
2006
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689739
Lin
An arsenic metallochaperone fo ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
103
15617-15622
2006
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