Information on EC - arsenite-transporting ATPase

for references in articles please use BRENDA:EC7.3.2.7
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IUBMB Comments
This bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. The enzyme usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. It forms an arsenite efflux pump that removes arsenite from the cytoplasm, and can also remove antimonite anions.
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Word Map
  • metalloid
  • sbiii
  • tail-anchored
  • antimonials
  • arsd
  • metallochaperone
  • oxyanions
  • trivalent
  • oxyanion-translocating
  • anion-translocating
The enzyme appears in viruses and cellular organisms
asna1, arsa atpase, asna-1, arsab, arsab pump, giarsa, riarsb, arsenite-translocating atpase, arsab extrusion pump, arsab as(iii) efflux pump, more
ATP + H2O + arsenite[side 1] = ADP + phosphate + arsenite[side 2]
show the reaction diagram
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