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Literature summary for 7.3.2.5 extracted from
- Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins (2013), Proc. Natl. Acad. Sci. USA, 110, 5440-5445.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Haemophilus influenzae |
- |
Archaeoglobus fulgidus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| vanadate | - |
Archaeoglobus fulgidus |  |
| vanadate | - |
Haemophilus influenzae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | transporter component interaction kinetics and affinities, overview | Haemophilus influenzae | |
| additional information | - |
additional information | transporter component interaction kinetics and affinities, overview | Archaeoglobus fulgidus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Haemophilus influenzae | |
| Mg2+ | required | Archaeoglobus fulgidus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + molybdate/out | Haemophilus influenzae | - |
ADP + phosphate + molybdate/in | - |
? | |
| ATP + H2O + molybdate/out | Archaeoglobus fulgidus | - |
ADP + phosphate + molybdate/in | - |
? | |
| additional information | Haemophilus influenzae | the enzyme is an ABC importer with substrate specificity for molybdate and tungstate | ? | - |
? | |
| additional information | Archaeoglobus fulgidus | the enzyme is an ABC importer with substrate specificity for molybdate and tungstate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Archaeoglobus fulgidus | - |
- |
- |
| Archaeoglobus fulgidus | O30144 | ModC | - |
| Haemophilus influenzae | - |
- |
- |
| Haemophilus influenzae | Q4QJQ0 | ATPase ModC | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Haemophilus influenzae |
- |
Archaeoglobus fulgidus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + molybdate/out | - |
Haemophilus influenzae | ADP + phosphate + molybdate/in | - |
? | |
| ATP + H2O + molybdate/out | - |
Archaeoglobus fulgidus | ADP + phosphate + molybdate/in | - |
? | |
| additional information | the enzyme is an ABC importer with substrate specificity for molybdate and tungstate | Haemophilus influenzae | ? | - |
? | |
| additional information | the enzyme is an ABC importer with substrate specificity for molybdate and tungstate | Archaeoglobus fulgidus | ? | - |
? | |
| additional information | component afMolA binds its substrates with high affinity, the affinity toward tungstate is higher. Binding of molybdate by afModA is endothermic, while that of tungstate is exothermic. Reconstitution of the detergent-free enzyme components BCA into liposomes and analysis of interaction between proteins BC and protein A, effects of nucleotides and substrates on the interaction, modeling of the mechanism, overview | Archaeoglobus fulgidus | ? | - |
? | |
| additional information | component hiMolA binds its substrates with low affinity.Reconstitution of the detergent-free enzyme components BCA into liposomes and analysis of interaction between proteins BC and protein A, effects of nucleotides and substrates on the interaction, overview | Haemophilus influenzae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the 20 transmembrane alpha-helices of enzyme components hiMolBC present a type II fold | Haemophilus influenzae |
| More | the enzyme components afModBC have 12 transmembrane alpha-helices that adopt the characteristic fold of type I ABC importers | Archaeoglobus fulgidus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| afModBCA | - |
Archaeoglobus fulgidus |
| hiMolBCA | - |
Haemophilus influenzae |
| ModBCA | - |
Archaeoglobus fulgidus |
| MolBCA | - |
Haemophilus influenzae |
| molybdate/tungstate ABC transporter | - |
Haemophilus influenzae |
| molybdate/tungstate ABC transporter | - |
Archaeoglobus fulgidus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Haemophilus influenzae |
| 7.5 | - |
assay at | Archaeoglobus fulgidus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | three-dimensional structure modeling | Haemophilus influenzae |
| additional information | three-dimensional structure modeling | Archaeoglobus fulgidus |
| physiological function | afModBCA is a high-affinity transport system for molybdate and tungstate anions | Archaeoglobus fulgidus |
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Release 2023.1 (January 2023)
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