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Literature summary for 7.3.2.5 extracted from
- Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein, MolA (2011), Structure, 19, 1701-1710.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene molA, recombinant expression | Haemophilus influenzae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| MolA bound to tungstate and molybdate, X-ray diffraction structure determination and analysis at 1.6 A resolution | Haemophilus influenzae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + molybdate/out | Haemophilus influenzae | - |
ADP + phosphate + molybdate/in | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
genes HI1472, HI1471, and HI1470 or molABC | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant MolA by affinity chromatography | Haemophilus influenzae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + molybdate/out | - |
Haemophilus influenzae | ADP + phosphate + molybdate/in | - |
? | |
| additional information | the MolA binding protein binds molybdate and tungstate but not other oxyanions such as sulfate and phosphate, it is thus a class III molybdate binding protein | Haemophilus influenzae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | structure of MolA falls into the cluster A of a class III periplasmic binding protein with two topologically similar globular domains, domain I and II correspond to residues 1-175 and 197-322, respectively, MolA topology and binding coordination, overview | Haemophilus influenzae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HI1470/71 | - |
Haemophilus influenzae |
| MolA | - |
Haemophilus influenzae |
| MolB2C2 | - |
Haemophilus influenzae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | periplasmic binding protein MolA delivers substrate to the ABC transporter MolB2C2 | Haemophilus influenzae |
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