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Literature summary for 7.1.1.9 extracted from
- Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42 (2005), J. Neurosci., 25, 672-679.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | amyloid beta which is involved in Alzheimers disease, specifically inhibits cytochrome-c oxidase | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amyloid beta1-42 | synthetic peptide, dimeric amyloid beta specifically inhibits the cytochrome-c oxidase dependent on presence of Cu2+ and specific ageing of the amyloid beta1-42 solution | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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Release 2023.1 (January 2023)
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