Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Enterococcus faecalis | |
5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Escherichia coli | |
5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Homo sapiens | |
5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Streptococcus pneumoniae | |
5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Enterococcus faecalis | |
5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Escherichia coli | |
5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Homo sapiens | |
5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-4'-phosphopantothenate + L-cysteine | Escherichia coli | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | Homo sapiens | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | Enterococcus faecalis | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | Streptococcus pneumoniae | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecalis | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Escherichia coli | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Homo sapiens | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Enterococcus faecalis | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Streptococcus pneumoniae | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Escherichia coli | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Homo sapiens | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Enterococcus faecalis | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Streptococcus pneumoniae | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CoaB | - |
Escherichia coli |
CoaB | - |
Homo sapiens |
CoaB | - |
Enterococcus faecalis |
CoaB | - |
Streptococcus pneumoniae |
phosphopantothenoylcysteine synthetase | - |
Escherichia coli |
phosphopantothenoylcysteine synthetase | - |
Homo sapiens |
phosphopantothenoylcysteine synthetase | - |
Enterococcus faecalis |
phosphopantothenoylcysteine synthetase | - |
Streptococcus pneumoniae |
PPCS | - |
Escherichia coli |
PPCS | - |
Homo sapiens |
PPCS | - |
Enterococcus faecalis |
PPCS | - |
Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
0.000065 | - |
pH and temperature not specified in the publication | Enterococcus faecalis | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
0.000068 | - |
pH and temperature not specified in the publication | Escherichia coli | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
0.003 | - |
pH and temperature not specified in the publication | Escherichia coli | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
0.01 | - |
pH and temperature not specified in the publication | Homo sapiens | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
0.013 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
0.018 | - |
pH and temperature not specified in the publication | Enterococcus faecalis | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
2.7 | - |
pH and temperature not specified in the publication | Homo sapiens | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine |